- 3-Bromo-7-azaindole
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2026-09-15
- CAS:74420-15-8
- Min. Order: 1G
- Purity: 90%min
- Supply Ability: 30kg/month
- 3-Bromo-7-azaindole
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- $1.00
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2019-07-12
- CAS:74420-15-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100kg
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| | 3-Bromo-7-azaindole Basic information |
| Product Name: | 3-Bromo-7-azaindole | | Synonyms: | 3-BROMO-7-AZAINDOLE;1H-PYRROLO[2,3-B]PYRIDINE, 3-BROMO-;3-Bromo-7-azaindole (3-bromo-1H-pyrrolo[2,3-b]pyridine）;3-broMo-1H-pyrrolo[2,3-b]pyridine 5-(trifluoroMethyl)-1H-iMidazole;3-BroMo-pyrrolo[2,3-b]pyridine;3-Bromo-7-azaindole 97%;1,2,3,4,5-Cyclopentanepentayl,1-[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2-[(R)-(dimethylamino)phenylmethyl]-,ironsalt(2:5);3-BROMO-1H-PYRROLO[2,3-B]PYRIDINE | | CAS: | 74420-15-8 | | MF: | C7H5BrN2 | | MW: | 197.03 | | EINECS: | | | Product Categories: | Azaindoles;Halides;CHIRAL CHEMICALS;Fused Ring Systems;Azaindole;Building Blocks;Indole Derivatives;Miscellaneous Reagents;Heterocycles | | Mol File: | 74420-15-8.mol |  |
| | 3-Bromo-7-azaindole Chemical Properties |
| Melting point | 185-189 °C | | Boiling point | 345.4±42.0 °C(Predicted) | | density | 1.79±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | Dichloromethane, Ethyl Acetate | | pka | 5.89±0.20(Predicted) | | form | Powder | | color | White to brown | | InChI | 1S/C7H5BrN2/c8-6-4-10-7-5(6)2-1-3-9-7/h1-4H,(H,9,10) | | InChIKey | VJDGIJDCXIEXPF-UHFFFAOYSA-N | | SMILES | Brc1c[nH]c2ncccc12 | | CAS DataBase Reference | 74420-15-8(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 22-37/38-41 | | Safety Statements | 26-36/37/39 | | RIDADR | UN 2811 | | WGK Germany | 3 | | Hazard Note | Irritant | | HazardClass | 6.1 | | PackingGroup | Ⅲ | | HS Code | 29339900 | | Storage Class | 6.1D - Non-combustible acute toxic Cat.3
toxic hazardous materials or hazardous materials causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 3-Bromo-7-azaindole Usage And Synthesis |
| Chemical Properties | 3-Bromo-7-azaindole is Yellow solid | | Uses | 3-Bromo-7-azaindole is a reagent used in the preparation of biologically active Azaindoles. | | Uses | Useful starter in 7-azaindole chemistry | | Synthesis | General procedure for the synthesis of 3-bromo-1H-pyrrolo[2,3-b]pyridine from 7-azaindole: 100 mmol of 7-azaindole was dissolved in an appropriate amount of organic solvent and transferred to the reactor. Subsequently, 40 mmol of catalyst consisting of nickel(II) acetate mixed with triethanolamine borosilicate in a 3:1 ratio was added. The temperature of the reaction system was adjusted to 100 °C and the stirring speed was maintained at 90 rpm. The reaction was carried out by slowly passing 300 mmol of bromine gas and refluxed for 3 hours. After completion of the reaction, the target product 3-bromo-7-azaindole was obtained in 99.0% yield after purification. | | References | [1] Patent: CN106349242, 2017, A. Location in patent: Paragraph 0033; 0034; 0035; 0036; 0037; 0038
[2] European Journal of Medicinal Chemistry, 2016, vol. 108, p. 701 - 719
[3] Patent: WO2013/6634, 2013, A2. Location in patent: Paragraph 0379-0382
[4] Patent: WO2013/70606, 2013, A1. Location in patent: Paragraph 00383-00385
[5] Patent: WO2014/74471, 2014, A1. Location in patent: Paragraph 0268-0270 |
| | 3-Bromo-7-azaindole Preparation Products And Raw materials |
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