Mal-PEG1-Bromide

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Mal-PEG1-Bromide Basic information
Product Name:Mal-PEG1-Bromide
Synonyms:Mal-PEG1-Bromide;1H-Pyrrole-2,5-dione, 1-[2-(2-bromoethoxy)ethyl]-;1-[2-(2-bromoethoxy)ethyl]-2,5-dihydro-1H-pyrrole-2,5-dione;1-(2-(2-bromoethoxy)ethyl)-1H-pyrrole-2,5-dione
CAS:1823885-81-9
MF:C8H10BrNO3
MW:248.07
EINECS:
Product Categories:
Mol File:1823885-81-9.mol
Mal-PEG1-Bromide Structure
Mal-PEG1-Bromide Chemical Properties
Boiling point 358.1±22.0 °C(Predicted)
density 1.588±0.06 g/cm3(Predicted)
solubility Soluble in DMSO, DCM, DMF
pka-2.35±0.20(Predicted)
Safety Information
MSDS Information
Mal-PEG1-Bromide Usage And Synthesis
DescriptionMal-PEG1-Bromide contains a maleimide group and bromide group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions.
UsesMal-PEG1-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50PEGs
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Mal-PEG1-Bromide Preparation Products And Raw materials
Tag:Mal-PEG1-Bromide(1823885-81-9) Related Product Information
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