Maleimido-Tri(Ethylene Glycol)-Propionic Acid

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Maleimido-Tri(Ethylene Glycol)-Propionic Acid manufacturers

  • Mal-PEG3-acid
  • Mal-PEG3-acid pictures
  • 2025-06-07
  • CAS:518044-40-1
  • Min. Order: 5g
  • Purity: >98.00%
  • Supply Ability: 5g
Maleimido-Tri(Ethylene Glycol)-Propionic Acid Basic information
Product Name:Maleimido-Tri(Ethylene Glycol)-Propionic Acid
Synonyms:3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5-hydroxy-2,2-bis(2-hydroxyethyl)pentanoic acid;Mal-PEG3-acid;Maleimide-PEG3-CH2CH2COOH;Mal-PEG3-COOH;Maleimido-Tri(Ethylene Glycol)-Propionic Acid;Propanoic acid, 3-[2-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]ethoxy]-;3-(2,5-dioxopyrrol-1-yl)-5-hydroxy-2,2-bis(2-hydroxyethyl)pentanoic acid;Mai-PEG3-acid
CAS:518044-40-1
MF:C13H19NO7
MW:301.29
EINECS:
Product Categories:peg
Mol File:518044-40-1.mol
Maleimido-Tri(Ethylene Glycol)-Propionic Acid Structure
Maleimido-Tri(Ethylene Glycol)-Propionic Acid Chemical Properties
Boiling point 491.4±40.0 °C(Predicted)
density 1.293±0.06 g/cm3(Predicted)
storage temp. Storage temp. 2-8°C
form Liquid
pka4.28±0.10(Predicted)
color Colorless to light yellow
Safety Information
MSDS Information
Maleimido-Tri(Ethylene Glycol)-Propionic Acid Usage And Synthesis
DescriptionMal-PEG3-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biological ActivityMaleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). It was used in the preparation of neolymphostin-based ADC precursors for the conjugation of site-specific cysteine mutant trastuzumab-A114C. Maleimido-tri(ethylene glycol)-propionic acid can also be used as a PEG-based PROTAC Linker for the synthesis of PROTACs.
in vitro

Mal-PEG3-C2-acid can be used to synthesize linker-payload 16 (compound 15) and 20 (compound 18). linker-payload 16 amd 20 is conjugated to DAR1.9 and DAR1.7. ADC 23 and 24 are Neolymphostin ADCs that composes of DAG 1.9 and DAG1.7 linked to PIKK inhibitors with linker-payload 16 and 20, respectively. ADC24 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC 50 of 195 and 202 nM, respectively. ADC23 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC 50 of 286 and 274 nM, respectively.

target

Cleavable

PEGs

Maleimido-Tri(Ethylene Glycol)-Propionic Acid Preparation Products And Raw materials
Raw materialsMal-PEG2-t-butyl ester-->N-Methoxycarbonylmaleimide-->tert-Butyl 12-amino-4 7 10-trioxa-dodeca-->Maleic anhydride
Tag:Maleimido-Tri(Ethylene Glycol)-Propionic Acid(518044-40-1) Related Product Information
Mal-PEG4-Acid Mal-PEG1-NHS ester alpha-MaleiMidopropionyl-oMega-succiniMidyl-6(ethylene glycol) Mal-PEG2-amine Mal-PEG3-NHS ester Mal-PEG6-COOH N-Succinimidyl 3-maleimidopropionate Mal-PEG4-NHS ester 3,4-Dibromo-Mal-PEG2-Amine Mal-PEG2-COOH N-[4-(-Carboxycyclohexylmethyl)]maleimide Mal-PEG2-NHS ester Bis-Mal-Lysine-PEG4-TFP ester Maleimide-PEG4-NHS Ester Maleimide-PEG2-NHS Ester 3-Maleimidopropionic acid Mal-PEG2-acid Mal-Amido-PEG4-acid
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