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| | Azido-PEG3-S-PEG4-propargyl Basic information |
| | Azido-PEG3-S-PEG4-propargyl Chemical Properties |
| | Azido-PEG3-S-PEG4-propargyl Usage And Synthesis |
| Description | Azido-PEG3-S-PEG4-propargyl is a crosslinker containing a propargyl group and an azide group. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. The azide group enables PEGylation via Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. | | Uses | Azido-PEG3-S-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-S-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Azido-PEG3-S-PEG4-propargyl Preparation Products And Raw materials |
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