17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α manufacturers
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| | 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α Basic information |
| | 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml |
| | 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α Usage And Synthesis |
| Description | A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects. 17-trifluoromethylphenyl-13,14-dihydro trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl-13,14-dihydro trinor PGF2α would act very much like the free acid of latanoprost. | | Uses | 17-Trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α is a derivative of Bimatoprost acid (HY-125774)[1]. | | References | [1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] Travoprost[J]. Reactions Weekly, 2009, 22 1: 40-41. DOI: 10.2165/00128415-200912530-00134
[3] BAHRAM RESUL. Phenyl-substituted prostaglandins: potent and selective antiglaucoma agents[J]. Journal of Medicinal Chemistry, 1993, 36 2: 243-248. DOI: 10.1021/jm00054a008 |
| | 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α Preparation Products And Raw materials |
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