METHOXY-(-)-VERAPAMIL HYDROCHLORIDE

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Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.  
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Email: sales@molcore.com

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METHOXY-(-)-VERAPAMIL HYDROCHLORIDE Basic information
Product Name:METHOXY-(-)-VERAPAMIL HYDROCHLORIDE
Synonyms:(-)-VERAPAMIL, METHOXY-, HYDROCHLORIDE;(-)-METHOXYVERAPAMIL HYDROCHLORIDE;METHOXY-(-)-VERAPAMIL HYDROCHLORIDE;(-)-D 600;(-)-Gallopamil;(-)-Methoxyverapamil;Gallopamil, ( ) ,Gallopamil, ();Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4,5-trimethoxy-α-(1-methylethyl)-, (αS)-
CAS:36622-40-9
MF:C28H40N2O5
MW:484.63
EINECS:
Product Categories:Calcium Channel Modulators;Verapamil;Voltage-gated Ion Channels
Mol File:36622-40-9.mol
METHOXY-(-)-VERAPAMIL HYDROCHLORIDE Structure
METHOXY-(-)-VERAPAMIL HYDROCHLORIDE Chemical Properties
Boiling point 605.9±55.0 °C(Predicted)
density 1.068±0.06 g/cm3(Predicted)
solubility H2O: soluble
pka8.96±0.50(Predicted)
Safety Information
WGK Germany 3
MSDS Information
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SigmaAldrich English
METHOXY-(-)-VERAPAMIL HYDROCHLORIDE Usage And Synthesis
Uses(-)-Gallopamil exerts a selective modulation of the fast voltage-dependent inactivation. (-)-Gallopamil inhibits efficiently Cav1.2 constructs formed by β-subunits (promoting fast voltage-dependent inactivation). (-)-Gallopamil also accelerates the voltage-dependent phase of ICa decay (as well as the voltage-dependent decay of Ba2+ currents). (-)-Gallopamil is promising for research of antiarrhythmics[1][2].
References[1] Sokolov S, et al. On the role of Ca(2+)- and voltage-dependent inactivation in Ca(v)1.2 sensitivity for the phenylalkylamine (-)gallopamil. Circ Res. 2001 Oct 12;89(8):700-8. DOI:10.1161/hh2001.098983
[2] Sokolov S, et al. Inactivation determinant in the I-II loop of the Ca2+ channel alpha1-subunit and beta-subunit interaction affect sensitivity for the phenylalkylamine (-)gallopamil. J Physiol. 1999 Sep 1;519 Pt 2(Pt 2):315-22. DOI:10.1111/j.1469-7793.1999.0315m.x
METHOXY-(-)-VERAPAMIL HYDROCHLORIDE Preparation Products And Raw materials
Tag:METHOXY-(-)-VERAPAMIL HYDROCHLORIDE(36622-40-9) Related Product Information
5-TERT-BUTYLPYROGALLOL 3,4,5-Trimethoxyphenylacetonitrile 3-tert-Butylphenol 4-HYDROXY-3-METHOXYPHENYLACETONITRILE R(+)-VERAPAMIL HYDROCHLORIDE (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile (3,4-DIHYDROXYPHENYL)ACETONITRILE (3-Methoxyphenyl)acetonitrile (3,4-Dimethoxyphenyl)acetonitrile METHOXY-(-)-VERAPAMIL HYDROCHLORIDE 3-Methylbutanenitrile (+/-)-Verapamil hydrochloride 2-PHENYLBUTYRONITRILE 3-Methyl-2-(3,4-dimethoxyphenyl)butyronitrile 4-Methoxybenzyl cyanide Trimethylacetonitrile 2-(4-Methoxyphenyl)-2-methylpropanenitrile METHOXYVERAPAMIL HYDROCHLORIDE