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| | Methyl oxindole-5-carboxylate Basic information |
| | Methyl oxindole-5-carboxylate Chemical Properties |
| Melting point | 192-199 | | Boiling point | 405.6±45.0 °C(Predicted) | | density | 1.283±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 13.43±0.20(Predicted) | | color | Very Dark Red to Very Dark Brown | | InChI | InChI=1S/C10H9NO3/c1-14-10(13)6-2-3-8-7(4-6)5-9(12)11-8/h2-4H,5H2,1H3,(H,11,12) | | InChIKey | CYBPPDZFRDSSME-UHFFFAOYSA-N | | SMILES | N1C2=C(C=C(C(OC)=O)C=C2)CC1=O | | CAS DataBase Reference | 199328-10-4(CAS DataBase Reference) |
| Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | Hazard Note | Harmful | | HS Code | 2933790090 |
| | Methyl oxindole-5-carboxylate Usage And Synthesis |
| Uses | Methyl indole-5-carboxylate may be used as a reactant in the following processes: biosynthesis of inhibitors of protein kinases metal-free Friedel-Crafts alkylation preparation of diphenylsulfonium ylides from Martin′s sulfurane.
| | Synthesis | At atmospheric pressure saturated with carbon monoxide, 5-iodo-2-hydroxyindole (17 g) was mixed with 2 g of
palladium diacetate, 18.2 triethylamine, 150 mL of methanol, 15 mL of dimethyl sulfoxide, and 2.6 g of DPPP was refluxed. after 24 h, the reaction mixture was filtered to remove the catalyst and the filtrate was concentrated. Make
The concentrate was chromatographed on silica gel using 30% ethyl acetate in hexane. The fraction containing the product was concentrated and allowed to stand. The product precipitates and is collected by vacuum filtration to give 0.8 g (7%) of as an off-white solid.
Methyl 5-carboxylate dihydroindol-2-one as an off-white solid. |
| | Methyl oxindole-5-carboxylate Preparation Products And Raw materials |
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