4-Bromo-2-fluorobenzylamine

4-Bromo-2-fluorobenzylamine Suppliers list

Company Name:	Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:	4006356688 18621169109
Email:	market03@meryer.com

Company Name:	JinYan Chemicals(ShangHai) Co.,Ltd.
Tel:	13817811078
Email:	sales@jingyan-chemical.com

4-Bromo-2-fluorobenzylamine manufacturers

4-Bromo-2-fluorobenzylamine Basic information

Product Name:	4-Bromo-2-fluorobenzylamine
Synonyms:	RARECHEM AL BW 0772;TIMTEC-BB SBB005778;2-FLUORO-4-BROMOBENZYL AMINE;2-Fluoro-4-Bromobenzylamine HCl;4-Bromo-2-fluorobenzylamine,99%;4-BroMo-2-fluorobenzylaMine, 99% 5GR;(4-broMo-2-fluorophenyl)MethanaMine hydrochloride;Benzenemethanamine, 4-bromo-2-fluoro-
CAS:	112734-22-2
MF:	C7H7BrFN
MW:	204.04
EINECS:
Product Categories:	Fluorine series;Anilines, Aromatic Amines and Nitro Compounds;Amine
Mol File:	112734-22-2.mol

4-Bromo-2-fluorobenzylamine Chemical Properties

Boiling point	244.5±25.0 °C(Predicted)
density	1.571±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	8.43±0.10(Predicted)
form	Liquid
Specific Gravity	1.58
color	Clear colorless to slightly yellow
InChI	InChI=1S/C7H7BrFN/c8-6-2-1-5(4-10)7(9)3-6/h1-3H,4,10H2
InChIKey	RLTFBWCBGIZCDQ-UHFFFAOYSA-N
SMILES	C1(CN)=CC=C(Br)C=C1F
CAS DataBase Reference	112734-22-2(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
ACROS	English

4-Bromo-2-fluorobenzylamine Usage And Synthesis

Chemical Properties	Clear colorless to slightly yellow liquid
Synthesis	105942-08-3 112734-22-2 General procedure for the synthesis of (4-bromo-2-fluorophenyl)methanamine from 4-bromo-2-fluorobenzonitrile: 4-bromo-2-fluorobenzonitrile (5.00 mmol) was dissolved in tetrahydrofuran (THF, 30 mL) and the solution was cooled to 0°C. A solution of borane tetrahydrofuran complex (1 M solution of THF, 15.0 mL) was added slowly and dropwise with stirring. The reaction mixture was continued to be stirred at 0 °C for 20 min, followed by warming to room temperature and stirring for 16 hours. Upon completion of the reaction, methanol (MeOH, 30 mL) was added slowly and dropwise to quench the reaction, followed by concentration of the solution under reduced pressure. The residue was extracted by partitioning with 1 M aqueous sodium hydroxide (NaOH) and ethyl acetate (EtOAc). The organic layer was separated and post-processed to give (4-bromo-2-fluorophenyl)methylamine (5.00 mmol) as a yellow oil.1H NMR (400 MHz, CDCl3) data: δ 7.42-7.27 (m, 1H), 7.25-7.16 (m, 2H), 3.65 (t, J = 6.6 Hz, 2H).
References	[1] Journal of Organic Chemistry, 2008, vol. 73, # 5, p. 1898 - 1905 [2] Journal of Organic Chemistry, 2009, vol. 74, # 5, p. 1964 - 1970 [3] Patent: WO2017/103611, 2017, A1. Location in patent: Paragraph 00336 [4] Patent: WO2018/75871, 2018, A1. Location in patent: Page/Page column 62

4-Bromo-2-fluorobenzylamine Preparation Products And Raw materials

Raw materials	Ethanol-->Palladium-->4-Bromo-2-fluorobenzonitrile-->Borane THF-->Tetrahydrofuran
Preparation Products	(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone

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