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BOC Sciences |
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1-631-485-4226; 16314854226 |
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info@bocsci.com |
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Sigma-Aldrich |
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Ogerin manufacturers
- Ogerin
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- $65.00
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2026-07-17
- CAS:1309198-71-7
- Purity: 99.50%
- Supply Ability: 10g
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| Product Name: | Ogerin | | Synonyms: | Ogerin;2-[4-Amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol;Benzenemethanol, 2-[4-amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]-;Ogerin >=98% (HPLC);G Protein-Coupled Receptor 68,Inhibitor,TGF-β,inhibit,fibroblasts,fibrotic diseases,Ogerin,GPR68,HEK293,A2A;Ogerin, 10 mM in DMSO;(2-(4-Amino-6-(benzylamino)-1,3,5-triazin-2-yl)phenyl)methanol;Ogerin[SML1482] | | CAS: | 1309198-71-7 | | MF: | C17H17N5O | | MW: | 307.35 | | EINECS: | | | Product Categories: | | | Mol File: | 1309198-71-7.mol |  |
| | Ogerin Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: 50 mg/ml | | form | powder | | color | white to beige | | InChI | 1S/C17H17N5O/c18-16-20-15(14-9-5-4-8-13(14)11-23)21-17(22-16)19-10-12-6-2-1-3-7-12/h1-9,23H,10-11H2,(H3,18,19,20,21,22) | | InChIKey | MDGIEDNDSFMSLP-UHFFFAOYSA-N | | SMILES | OCC1=C(C2=NC(NCC3=CC=CC=C3)=NC(N)=N2)C=CC=C1 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | Ogerin Usage And Synthesis |
| Uses | Ogerin is a potent GPR68 modulator. | | Biochem/physiol Actions | Ogerin is a selective positive allosteric modulator of an orphan GPCR, GPR68, also known as Ovarian cancer G-protein coupled receptor 1 (OGR1). GPR68 is one of the proton or pH-sensing GPCRs that sense extracellular H(+). Ogerin potently potentiated proton-mediated GPR68-Gs signaling. Ogerin was not active in GPR68 knockout mice, but was found to suppress recall in fear conditioning in wild-type mice, showing an unexpected effect of GPR68 on learning and memory. | | Enzyme inhibitor | This GPR68 activator (FW = 307.35 g/mol; CAS 1309198-71-7), also named 2-[4-amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol, selectively and allosterically targets G-Protein-coupled Receptor 68, one of at least 120 non-olfactory G-protein-coupled receptors in the human genome that remain 'orphans' (i.e., they are pharmacologically dark, with no known endogenous ligands). Ogerin suppresses recall in fear conditioning in wild-type, but not in GPR68-knockout mice. GPR68 is also a newly recognized metastasis suppressor gene in certain cancers. | | in vivo | Ogerin (10 mg/kg; single) shows effects that supports a role for GPR68 in hippocampal-associated memory[2]. | Animal Model: | GPR68 knockout and WT mice[2]. | | Dosage: | 10 mg/kg | | Administration: | Single (30 min before the training) | | Result: | Suppressed recall in fear conditioning in wild-type, but not in GPR68 knockout mice. |
| | storage | Store at -20°C |
| | Ogerin Preparation Products And Raw materials |
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