GW583340 dihydrochloride

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GW583340 dihydrochloride Suppliers list
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 18930552037
Email: 3bsc@sina.com
Company Name: EMMX Biotechnology LLC  
Tel: 888-539-0666
Email: info@emmx.com
Company Name: TargetMol  
Tel: 400-821-0310 15002144251
Email: xuexiang.shao@tsbiochem.com
GW583340 dihydrochloride Basic information
Product Name:GW583340 dihydrochloride
Synonyms:4-[3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY]P;4-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenylamino]-6-[2-[[2-(methylsulfonyl)ethyl]aminomethyl]-4-thiazolyl]quinazoline dihydrochloride;N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinaminedihydrochloride;4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-;GW 583340
CAS:388082-81-3
MF:C28H25ClFN5O3S2
MW:598.11
EINECS:
Product Categories:
Mol File:388082-81-3.mol
GW583340 dihydrochloride Structure
GW583340 dihydrochloride Chemical Properties
Melting point 259.8-262.4 °C(lit.)
storage temp. 2-8°C
solubility DMSO: 9 mg/mL
form solid
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
MSDS Information
GW583340 dihydrochloride Usage And Synthesis
DefinitionChEBI: N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[(2-methylsulfonylethylamino)methyl]-4-thiazolyl]-4-quinazolinamine is a member of quinazolines.
Biological ActivityPotent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC 50 values are 0.01 and 0.014 μ M respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2: IC 50 values are 0.11 μ M for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μ M for inhibition of non-tumor cell line HFF. In vivo, inhibits tumor growth by ~ 80% in a murine xenograft model following oral administration.
GW583340 dihydrochloride Preparation Products And Raw materials
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