3-Chloro-4-fluorophenylmagnesium bromid&

3-Chloro-4-fluorophenylmagnesium bromid& Suppliers list

Company Name:	Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:	4006356688 18621169109
Email:	market03@meryer.com

Company Name:	Shanghai Hanhong Scientific Co.,Ltd.
Tel:	021-54306202 13764082696
Email:	info@hanhongsci.com

3-Chloro-4-fluorophenylmagnesium bromid& Basic information

Product Name:	3-Chloro-4-fluorophenylmagnesium bromid&
Synonyms:	3-CHLORO-4-FLUOROPHENYLMAGNESIUM BROMID&;3-Chloro-4-fluorophenylmagnesium bromide solution 0.5 M in THF;3-Chloro-4-fluorophenylmagnesium bromide, 0.50 M in THF;magnesium,1-chloro-2-fluorobenzene-5-ide,bromide;3-chloro-4-fluorophenylmagnesium bromide solution;3-Chloro-4-fluorophenylmagnesium bromide solution 0.5 in THF;3-Chloro-4-fluorophenylmagnesium bromide, 0.5M solution in THF, AcroSeal;broMo(3-chloro-4-fluorophenyl)MagnesiuM
CAS:	413589-34-1
MF:	C6H3BrClFMg
MW:	233.7484232
EINECS:
Product Categories:	Grignard Reagent;Chemical Synthesis;Grignard Reagents;Organometallic Reagents;Aryl;Grignard Reagents;Organometallic Reagents
Mol File:	413589-34-1.mol

3-Chloro-4-fluorophenylmagnesium bromid& Chemical Properties

Boiling point	65 °C
density	0.966 g/mL at 25 °C
Fp	1 °F
storage temp.	2-8°C
InChI	1S/C6H3ClF.BrH.Mg/c7-5-3-1-2-4-6(5)8;;/h2-4H;1H;/q;;+1/p-1
InChIKey	XRNCDMQVKMYTAM-UHFFFAOYSA-M
SMILES	Fc1ccc([Mg]Br)cc1Cl

Safety Information

Hazard Codes	F,C
Risk Statements	11-14-19-22-34-40-37
Safety Statements	16-26-36/37/39-45
RIDADR	UN 2924 3/PG 2
WGK Germany	1
HS Code	29310099
Storage Class	3 - Flammable liquids
Hazard Classifications	Acute Tox. 4 Oral Carc. 2 Eye Dam. 1 Flam. Liq. 2 Skin Corr. 1B STOT SE 3

MSDS Information

3-Chloro-4-fluorophenylmagnesium bromid& Usage And Synthesis

Preparation	Under an argon atmosphere, a trace amount of iodine was added to a mixture of magnesium (434 mg) and THF (2 mL). The mixture was heated to 60 °C, and a solution of 4-bromo-2-chloro-1-fluorobenzene (3.58 g) in THF (6.5 mL) was added dropwise (the temperature was maintained at 65 °C during the addition). The mixture was stirred at 60 °C for 30 minutes and then cooled to room temperature to give 3-CHLORO-4-FLUOROPHENYLMAGNESIUM BROMIDE.
Application	Magnesium 3-chloro-4-fluorophenyl bromide can be used as a pharmaceutical synthesis intermediate, such as in the preparation of pyrrolidine derivatives like (2R,5S)-1-(tert-butoxycarbonyl)-5-(3-chloro-4-fluorophenyl)pyrrolidine-2-carboxylic acid ethyl ester. This compound has antagonistic activity against the calcitonin gene-related peptide (CGRP) receptor and can be used to treat various diseases related to the CGRP receptor.
reaction suitability	reaction type: Grignard Reaction

3-Chloro-4-fluorophenylmagnesium bromid& Preparation Products And Raw materials

Tag:3-Chloro-4-fluorophenylmagnesium bromid&(413589-34-1) Related Product Information

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