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| | 6-BROMO-2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID Basic information |
| Product Name: | 6-BROMO-2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID | | Synonyms: | 6-bromo-2-keto-1H-quinoline-4-carboxylic acid;6-bromo-2-oxo-1H-quinoline-4-carboxylic acid;4-Quinolinecarboxylic acid, 6-bromo-1,2-dihydro-2-oxo-;6-Bromo-2-oxo-1,2-dihydroquinoline-5-carboxylic acid | | CAS: | 5463-29-6 | | MF: | C10H6BrNO3 | | MW: | 268.06 | | EINECS: | | | Product Categories: | | | Mol File: | 5463-29-6.mol |  |
| | 6-BROMO-2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID Chemical Properties |
| Boiling point | 446.7±45.0 °C(Predicted) | | density | 1.804±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 2.54±0.20(Predicted) | | Appearance | Off-white to light yellow Solid |
| HazardClass | IRRITANT | | HS Code | 2933491090 |
| | 6-BROMO-2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID Usage And Synthesis |
| Synthesis | 6-Bromo-2-hydroxy-4-carboxylic acid quinoline was synthesized using the method described in Scheme 6. The procedure was as follows: 5-bromoindoline-2,3-dione (0.250 g) was dissolved in tetrahydrofuran (THF, 3 ml) in a round-bottomed flask, followed by the addition of malonic acid (2 equiv). The unit was connected to a reflux condenser and heated to reflux by conventional heating and the reaction was continued overnight. After 12 hours of reaction, a solid precipitate was observed to be generated. Subsequently, the suspension was concentrated under reduced pressure to remove the solvent, and the suspension was refluxed for 4 hours after addition of an appropriate amount of water. Finally, the solid product was collected by filtration to afford 6-bromo-2-hydroxyquinoline-4-carboxylic acid (0.150 g) in solid form. | | References | [1] Patent: US2014/221387, 2014, A1. Location in patent: Paragraph 0383; 0384; 0385 |
| | 6-BROMO-2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID Preparation Products And Raw materials |
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