6-Bromo-2(1H)-quinolone

6-Bromo-2(1H)-quinolone Suppliers list

Company Name:	Shanghai Suifu Chemical Technology CO.,LTD. Gold
Tel:	33738187 19945655289
Email:	suifuchemical@163.com

Company Name:	BeiJing Hwrk Chemicals Limted
Tel:	0757-86329057 18934348241
Email:	sales4.gd@hwrkchemical.com

6-Bromo-2(1H)-quinolone manufacturers

6-Bromo-2(1H)-quinolone;2-Hydroxy-6-bromoquinoline;6-Bromo-2(1H)-quinolinone ada@tuskwei.com
$3.00
2018-09-26
CAS:1810-66-8
Min. Order: 1G
Purity: 99%
Supply Ability: 7000g/day ada@tuskwei.com whatsapp;+08617197824028

6-Bromo-2(1H)-quinolone Basic information

Product Name:	6-Bromo-2(1H)-quinolone
Synonyms:	6-BROMO-2-HYDROXYQUINOLINE;6-Bromo-2(1H)-quinolinone;6-Bromo-2-quinolinol;6-Bromocarbostyril;6-Bromo-2-hydroxyquinoline 98%;109404;6-Bromo-2-quinolinone;2-Hydroxy-6-bromoquinoline
CAS:	1810-66-8
MF:	C9H6BrNO
MW:	224.05
EINECS:
Product Categories:	Aromatics Compounds;CHIRAL CHEMICALS;Aromatics;Heterocycles
Mol File:	1810-66-8.mol

6-Bromo-2(1H)-quinolone Chemical Properties

Melting point	278-280C
Boiling point	393.8±42.0 °C(Predicted)
density	1.620±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO
pka	10.76±0.70(Predicted)
form	Solid
color	Beige
InChI	InChI=1S/C9H6BrNO/c10-7-2-3-8-6(5-7)1-4-9(12)11-8/h1-5H,(H,11,12)
InChIKey	YLAFBGATSQRSTB-UHFFFAOYSA-N
SMILES	N1C2=C(C=C(Br)C=C2)C=CC1=O

Safety Information

MSDS Information

6-Bromo-2(1H)-quinolone Usage And Synthesis

Chemical Properties	Beige Solid
Uses	6-Bromo-2(1H)-quinolinone is a useful intermediate for the synthesis of other quinoline derivatives.
Synthesis	327058-51-5 1810-66-8 General procedure for the synthesis of 6-bromoquinolin-2(1H)-one from the compound (CAS:327058-51-5): 6-bromo-2(1H)-quinolinone (6.0 g, 22.2 mmol) was dissolved in concentrated H2SO4 (30 mL) and the reaction was heated in an oil bath at 100 °C overnight. Upon completion of the reaction, the mixture was cooled to room temperature and quenched with ice water. The precipitate precipitated was collected by filtration, washed with water and subsequently dried under vacuum to afford 6-bromoquinolin-2(1H)-one as a white solid (4.8 g, 97% yield). Mass spectrum (ES+) m/e 225 [M+H]+.
References	[1] Patent: WO2006/132739, 2006, A2. Location in patent: Page/Page column 35-36 [2] Chemical and Pharmaceutical Bulletin, 2014, vol. 62, # 6, p. 508 - 518 [3] European Journal of Medicinal Chemistry, 2000, vol. 35, # 10, p. 931 - 940 [4] Journal of Medicinal Chemistry, 2005, vol. 48, # 1, p. 306 - 311

6-Bromo-2(1H)-quinolone Preparation Products And Raw materials

Raw materials	(2E)-N-(4-Bromophenyl)-3-ethoxy-2-propenamide-->6-bromo-2-methoxyquinoline-->N-(4-bromophenyl)cinnamamide-->4-Bromo-2-iodoaniline-->6-Bromoquinoline-->2-Propenamide, N-(4-bromophenyl)-3-ethoxy--->Sulfuric acid-->4-Bromoaniline-->2-Propenamide, N-(4-bromophenyl)-3-methoxy-, (2E)--->Ethyl acrylate
Preparation Products	2-Chloroquinoline-6-carbaldehyde-->6-Bromoquinolin-2-amine-->6-(1-Pyrazolyl)-2-quinolone

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