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| | 2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER Basic information |
| | 2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER Chemical Properties |
| Melting point | 147-149℃ | | Boiling point | 349℃ | | density | 1.261 | | Fp | 165℃ | | storage temp. | 2-8°C(protect from light) | | pka | 1.94±0.10(Predicted) | | Appearance | White to light yellow Solid |
| | 2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER Usage And Synthesis |
| Uses | 2-Amino-pyrimidine-5-carboxylic Acid Ethyl Ester is a reagent used in the synthesis of retinoidal pyrimidinecarboxylic acids. | | Synthesis | The general procedure for the synthesis of ethyl 2-aminopyrimidine-5-carboxylate from ethyl 2-methylsulfonyl-5-pyrimidinecarboxylate was as follows: ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate (2.15 g, 9.34 mmol) was dissolved in acetonitrile (11.7 mL) and stirred at room temperature. Subsequently, 32% aqueous ammonium hydroxide solution (11.36 mL, 93 mmol) was added slowly and dropwise. The reaction mixture transformed into a white suspension within seconds. The acetonitrile was removed by rotary evaporator and the remaining aqueous phase suspension was filtered through a Brinell funnel. The resulting solid was washed with distilled water (20 mL) and dried to give ethyl 2-aminopyrimidine-5-carboxylate as a white solid (1.192 g, 7.13 mmol, 76% yield, MS/ESI+ 168.1 [MH]+). | | References | [1] Patent: US2013/79313, 2013, A1. Location in patent: Paragraph 1024
[2] Patent: WO2013/45280, 2013, A1. Location in patent: Page/Page column 276 |
| | 2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials |
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