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| | SGK3 degrader-1 Basic information |
| Product Name: | SGK3 degrader-1 | | Synonyms: | SGK3 degrader-1;PROTAC SGK3 degrader-1;SGK3-PROTAC1;(2S,4R)-1-((S)-2-(tert-Butyl)-18-((R)-2-(((6-(4-((2-fluoro-5-methylphenyl)sulfonamido)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)methyl)morpholino)-4-oxo-6,9,12-trioxa-3-azaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide | | CAS: | 2381320-35-8 | | MF: | C57H73FN10O11S2 | | MW: | 1157.38 | | EINECS: | | | Product Categories: | PROTACs-Please select | | Mol File: | 2381320-35-8.mol |  |
| | SGK3 degrader-1 Chemical Properties |
| density | 1.309±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: ≥ 100 mg/mL (86.40 mM) | | form | Solid | | pka | 6.38±0.10(Predicted) | | color | White to off-white |
| | SGK3 degrader-1 Usage And Synthesis |
| Uses | PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a von Hippel-Lindau ligand-based SKG3 PROTAC composed of a PEG3-C4-OBn (HY-130620) alkyl linker, an SGK3 degrader (red structure), and a VHL ligand (HY-150803, blue structure). PROTAC SGK3 degrader-1 (0.3 μM) induced 50% endogenous SGK3 degradation within 2 hours, and 80% SGK3 degradation was observed at 8 hours, accompanied by loss of phosphorylation of NDRG1 (SGK3 substrate)[1]. | | IC 50 | SGK3 | | References | [1] Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034. DOI:10.1021/acschembio.9b00505 |
| | SGK3 degrader-1 Preparation Products And Raw materials |
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