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| | PROTAC MDM2 Degrader-1 Basic information |
| Product Name: | PROTAC MDM2 Degrader-1 | | Synonyms: | PROTAC MDM2 Degrader-1;1-Piperazineacetamide, N,N'-[oxybis(2,1-ethanediyloxy-3,1-propanediyl)]bis[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-oxo-, rel- | | CAS: | 2249944-98-5 | | MF: | C74H84Cl4N10O13 | | MW: | 1463.33 | | EINECS: | | | Product Categories: | PROTACs-Please select | | Mol File: | 2249944-98-5.mol |  |
| | PROTAC MDM2 Degrader-1 Chemical Properties |
| density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 14.46±0.46(Predicted) | | color | White to off-white |
| | PROTAC MDM2 Degrader-1 Usage And Synthesis |
| Uses | PROTAC MDM2 Degrader-1 (Compound 15a) is a MDM2 PROTAC degrader. The structures of both Linker ends of PROTAC MDM2 Degrader-1 are MDM2 ligands. PROTAC MDM2 Degrader-1 can not only block the binding of p53-MDM2, but also degrade the target MDM2 protein by utilizing the function of the E3 ligase of MDM2 itself, thus exerting an anti-tumor effect. (Pink: MDM2 ligand 2 (HY-128836); Black: Linker (HY-128844); Blue: E3 ligase Ligand 15 (HY-128836))[1] | | IC 50 | MDM2 | | References | [1] Method of inducing of self-degradation of MDM2 using E3 ubiquitin ligase dimer amide small molecule PROTACs. CN108610333A. |
| | PROTAC MDM2 Degrader-1 Preparation Products And Raw materials |
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