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- 9-Bromo-1-nonene
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2025-06-27
- CAS:89359-54-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500000kg
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| | 9-Bromo-1-nonene Basic information | | Uses |
| Product Name: | 9-Bromo-1-nonene | | Synonyms: | Non-8-en-1-yl bromide;9-Bromo-1-decene;9-Bromonon-1-ene 98%;1-Nonene, 9-bromo-;8-Nonenyl Bromide;9-BROMO-1-NONENE ISO 9001：2015 REACH;9-Bromo-1-nonene,98% (stabilized with MEHQ);9-BroMonon-1-ene | | CAS: | 89359-54-6 | | MF: | C9H17Br | | MW: | 205.14 | | EINECS: | | | Product Categories: | | | Mol File: | 89359-54-6.mol |  |
| | 9-Bromo-1-nonene Chemical Properties |
| Boiling point | 100-101℃/15mm | | density | 1.1034 (estimate) | | refractive index | 1.4675 | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | Liquid | | color | Colorless to pale yellow | | InChI | InChI=1S/C9H17Br/c1-2-3-4-5-6-7-8-9-10/h2H,1,3-9H2 | | InChIKey | RQXPBVHYVAOUBY-UHFFFAOYSA-N | | SMILES | C=CCCCCCCCBr |
| | 9-Bromo-1-nonene Usage And Synthesis |
| Uses | Non-8-enyl Bromide is a reactant in the synthesis of breast cancer drug, Fulvestrant (Falsodex). | | Uses | Non-8-enyl Bromide is a reactant in the synthesis of breast cancer drug, Fulvestrant (Falsodex). | | Synthesis | General procedure for the synthesis of 9-bromo-1-nonene from 8-nonen-1-ol: Triphenylphosphine (5.42 g, 20.67 mmol) was dissolved in 20 ml of acetonitrile and placed in a cold bath at -10 °C. Subsequently, bromine (1.01 ml, 19.83 mmol) was slowly added dropwise and the reaction mixture was stirred at that temperature for 30 min. Next, a solution of 8-nonen-1-ol (2 g, 14.06 mmol) and pyridine (1.8 ml, 22.36 mmol) in 10 ml of acetonitrile was added. The cold bath was removed and the reaction mixture was continued to be stirred at room temperature for 1 hour. After completion of the reaction, the solvent was removed by evaporation and the residue was purified by silica gel column chromatography using heptane as eluent. Finally, vacuum distillation was carried out through a bulb tube oven at 120 °C/1 mm Hg to give a colorless liquid product (1.44 g, 50% yield). | | References | [1] Tetrahedron Letters, 2013, vol. 54, # 29, p. 3865 - 3867
[2] Patent: WO2015/181116, 2015, A1. Location in patent: Page/Page column 51
[3] Journal of the Chemical Society, 1937, p. 1977
[4] Organic letters, 1999, vol. 1, # 2, p. 241 - 243 |
| | 9-Bromo-1-nonene Preparation Products And Raw materials |
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