L-Prolinamide, N-(8-amino-1-oxooctyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

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L-Prolinamide, N-(8-amino-1-oxooctyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Suppliers list
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L-Prolinamide, N-(8-amino-1-oxooctyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Basic information
Product Name:L-Prolinamide, N-(8-amino-1-oxooctyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
Synonyms:VH032-C7-amine;(2S,4R)-1-((S)-2-(8-Aminooctanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;VH032-C6-NH2;(2S,4R)-1-[(S)-2-(8-Aminooctanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-[4-(4-methyl-5-thiazolyl)benzyl]pyrrolidine-2-carboxamide;L-Prolinamide, N-(8-amino-1-oxooctyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(S,R,S)-AHPC-C7-amine
CAS:2306389-04-6
MF:C30H45N5O4S
MW:571.78
EINECS:
Product Categories:
Mol File:2306389-04-6.mol
L-Prolinamide, N-(8-amino-1-oxooctyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Structure
L-Prolinamide, N-(8-amino-1-oxooctyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Chemical Properties
Boiling point 839.2±65.0 °C(Predicted)
density 1.188±0.06 g/cm3(Predicted)
pka14.08±0.40(Predicted)
Safety Information
MSDS Information
L-Prolinamide, N-(8-amino-1-oxooctyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Usage And Synthesis
Uses(S,R,S)-AHPC-C7-amine (VH032-C7-amine) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader[1].
IC 50VHL
References[1] Lijie Peng, et al. Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation. ACS Med Chem Lett. 2019 Apr 12;10(5):767-772. DOI:10.1021/acsmedchemlett.9b00025
L-Prolinamide, N-(8-amino-1-oxooctyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Preparation Products And Raw materials
Tag:L-Prolinamide, N-(8-amino-1-oxooctyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-(2306389-04-6) Related Product Information
(S,R,S)-Ahpc-C6-NH2 L-Prolinamide, N-(9-amino-1-oxononyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- L-Prolinamide, N-[8-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxooctyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- VH032-C10-NH2 L-Prolinamide, N-(6-amino-1-oxohexyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- (S,R,S)-Ahpc-C4-NH2