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| | 4-Chloro-2-nitroaniline Basic information |
| | 4-Chloro-2-nitroaniline Chemical Properties |
| Melting point | 117-119 °C(lit.) | | Boiling point | 200°C (rough estimate) | | density | 1.37 | | refractive index | 1.6460 (estimate) | | Fp | 191 °C | | storage temp. | room temp | | solubility | 0.5g/l (anhydrous substance) | | pka | pK1: 1.10(+1) (25°C) | | Colour Index | 37040 | | form | Crystalline Powder or Chunks | | color | Orange | | PH | 7 (0.5g/l, H2O, 20℃) | | Water Solubility | INSOLUBLE | | BRN | 512436 | | Henry's Law Constant | 8.2×101 mol/(m3Pa) at 25℃, HSDB (2015) | | Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. | | InChI | 1S/C6H5ClN2O2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H,8H2 | | InChIKey | PBGKNXWGYQPUJK-UHFFFAOYSA-N | | SMILES | Nc1ccc(Cl)cc1[N+]([O-])=O | | CAS DataBase Reference | 89-63-4(CAS DataBase Reference) | | NIST Chemistry Reference | Aniline, 4-chloro-2-nitro-(89-63-4) | | EPA Substance Registry System | 4-Chloro-2-nitroaniline (89-63-4) |
| Hazard Codes | T+,N,T | | Risk Statements | 26/27/28-33-51/53 | | Safety Statements | 28-36/37-45-61-28A | | RIDADR | UN 2237 (CHLORONITROANILINES) | | WGK Germany | 2 | | RTECS | BX1575000 | | Autoignition Temperature | 964 °F | | Hazard Note | Very Toxic | | TSCA | TSCA listed | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29214210 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 1 Dermal
Acute Tox. 2 Inhalation
Acute Tox. 2 Oral
Aquatic Acute 1
Aquatic Chronic 2
STOT RE 2 | | Hazardous Substances Data | 89-63-4(Hazardous Substances Data) |
| | 4-Chloro-2-nitroaniline Usage And Synthesis |
| Chemical Properties | bright orange powder | | Uses | A nitro-aromatic amine with mutagenicity and carcinogenicity | | Uses | 4-Chloro-2-nitroaniline is used
almost exclusively as an intermediate in the synthesis of
pigments.
The greatest potential for human exposure to 4-chloro-2-
nitroaniline is in production and use of pigments made from
the compound. | | Uses | 4-Chloro-2-nitroaniline is used as pharmaceutical intermediate. | | Production Methods | 1,4-Dichloro-2-nitrobenzene is aminated at 165 ℃ by using a process similar to that described for 2- nitroaniline. | | Preparation | 4-Chloro-2-nitrobenzenamine of chlorine. | | General Description | Bright orange powder. | | Air & Water Reactions | Insoluble in water. | | Reactivity Profile | 4-Chloro-2-nitroaniline forms explosive products on reaction with nitric acid. Can react with oxidizing agents. | | Hazard | Toxic by ingestion and inhalation. | | Fire Hazard | 4-Chloro-2-nitroaniline is probably combustible. | | Purification Methods | Crystallise the aniline from hot H2O (m 115.8-116o), EtOH, EtOH/H2O or *C6H6, and dry it for 10hours at 60o in vacuo. It has m 115.5-116o after sublimation. [Beilstein 12 H 729, 12 I 355, 12 II 396, 12 III 1649, 12 IV 1669.] |
| | 4-Chloro-2-nitroaniline Preparation Products And Raw materials |
| Raw materials | 2,5-Dichloronitrobenzene-->4-Chloro-2-nitroaniline | | Preparation Products | Quizalofop-p-ethyl-->HANSA YELLOW 10G-->2-(2'-Hydroxy-3',5'-di-tert-butylphenyl)-5-chlorobenzotriazole-->N-Acetyl-N-(4-chloro-2-nitrophenyl)acetamide-->5-[(4-chloro-2-nitrophenyl)azo]-1-ethyl-1,2-dihydro-6-hydroxy-4-methyl-2-oxonicotinonitrile-->1,2,3,4-tetrahydro-Phenazine-->N-(2-Amino-4-chlorophenyl)anthranilic acid-->8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione-->4-Amino-3-nitrophenylboronic acid, pinacol ester-->5-Chloro-2-iodoaniline-->UV-320-->2,3,6-Trichloroquinoxaline-->DISPERSE YELLOW 211-->4-Chloro-2-nitroaniline |
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