- Ethyl 2-oxohexanoate
-
- $0.00 / 100g
-
2021-07-14
- CAS:5753-96-8
- Min. Order: 100g
- Purity: 98%
- Supply Ability: >100kg
- Ethyl 2-oxohexanoate
-
- $15.00 / 1KG
-
2021-07-13
- CAS:5753-96-8
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- Ethyl 2-oxohexanoate
-
- $15.00 / 1KG
-
2021-07-10
- CAS:5753-96-8
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
|
| | Ethyl 2-oxohexanoate Basic information |
| Product Name: | Ethyl 2-oxohexanoate | | Synonyms: | 2-oxohexanoic acid ethyl ester;ethyl alpha-ketocaproate;Ethyl 2-oxohexanoate;2-Ketocaproic acid ethyl ester;2-Oxyhexanoic acid ethyl ester;2-ketoHexanoicacidethylester;Hexanoic acid, 2-oxo-, ethyl ester;Ethyl 2-oxohexanoate - [E12153] | | CAS: | 5753-96-8 | | MF: | C8H14O3 | | MW: | 158.2 | | EINECS: | 1308068-626-2 | | Product Categories: | API | | Mol File: | 5753-96-8.mol |  |
| | Ethyl 2-oxohexanoate Chemical Properties |
| Boiling point | 96°C | | density | 0.981 | | Fp | 81°C | | storage temp. | Sealed in dry,Room Temperature | | Appearance | Light yellow to green yellowLiquid |
| | Ethyl 2-oxohexanoate Usage And Synthesis |
| Chemical Properties | Pale yellow liquid | | Synthesis Reference(s) | The Journal of Organic Chemistry, 29, p. 2080, 1964 DOI: 10.1021/jo01030a549 | | Synthesis | General procedure for the synthesis of ethyl 2-oxohexanoate from n-butylzinc bromide and monoethyl oxalyl chloride: a stirred solution of copper iodide (2.29 g, 12 mmol) in anhydrous tetrahydrofuran was cooled to -25 °C and a tetrahydrofuran solution of 0.5 M n-butylzinc bromide (24 mL, 12 mmol) was added slowly dropwise. After addition, the reaction mixture was warmed to 0 °C and stirred at that temperature for 20 min, then cooled to -25 °C again. The reaction mixture was treated dropwise with monoethyl oxalyl chloride (1.37 g, 10 mmol). After stirring at -25 °C for 3 h, the reaction mixture was warmed to room temperature, the reaction was quenched with saturated aqueous ammonium chloride solution and the aqueous layer was extracted with ether. The combined organic phases were washed with brine, filtered, dried over anhydrous sodium sulfate and concentrated in vacuum. The crude product was purified by ISCO fast column chromatography using a pre-populated RediSep silica gel column (gradient elution, 0→20% ethyl acetate in hexane solution) to afford ethyl 2-oxohexanoate (0.60 g, 37%) as a colorless oil.1H NMR (400 MHz, CDCl3) δ 0.91-0.98 (3H, m), 1.34- 1.47 (5H, m), 1.58-1.76 (2H, m), 2.83 (1H, t, J = 7.3 Hz), 4.27-4.37 (2H, m). | | References | [1] Patent: US2008/90814, 2008, A1. Location in patent: Page/Page column 23-24 |
| | Ethyl 2-oxohexanoate Preparation Products And Raw materials |
|