Sodium theophylline glycinate manufacturers
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| | Sodium theophylline glycinate Basic information |
| Product Name: | Sodium theophylline glycinate | | Synonyms: | Sodium 2-aminoacetate 1,3-dimethyl-7H-purine-2,6-dione;Sodium theophylline glycinate;THEOPHYLLINE SODIUM GLYCINATE USP/EP/BP;Sodium theophylline glycinate USP/EP/BP;Sodium theophylline glycite | | CAS: | 8000-10-0 | | MF: | C9H12N5NaO4 | | MW: | 277.21 | | EINECS: | 200-110-4 | | Product Categories: | | | Mol File: | 8000-10-0.mol |  |
| | Sodium theophylline glycinate Chemical Properties |
| | Sodium theophylline glycinate Usage And Synthesis |
| Uses | Theophylline (1,3-Dimethylxanthine) sodium glycinate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline sodium glycinate inhibits PDE3 activity to relax airway smooth muscle. Theophylline sodium glycinate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline sodium glycinate induces apoptosis. Theophylline sodium glycinate can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5]. | | in vivo | Theophylline sodium glycinate (100 mg/kg; i.p.; daily, for 9 d) has anti-inflammatory activity in mice and increases IL-6 and IL-10 levels and inhibits TNF-α and NO in male Swiss mice[1].
| Animal Model: | Male Swiss mice[1] | | Dosage: | 100 mg/kg | | Administration: | Intraperitoneal injection; daily; for 9 days | | Result: | Increased IL-6 and IL-10 levels and inhibited TNF-α and NO. |
| | IC 50 | IL-10; IL-6 | | References | [1] Rabe KF, et, al. Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants. Eur Respir J. 1995 Apr;8(4):637-42. PMID:7664866
[2] Németh ZH, et, al. Amrinone and theophylline differentially regulate cytokine and nitric oxide production in endotoxemic mice. Shock. 1997 May;7(5):371-5. DOI:10.1097/00024382-199705000-00010
[3] Ito K, et, al, Adcock IM, Barnes PJ. A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8921-6. DOI:10.1073/pnas.132556899
[4] Barnes PJ. Theophylline. Am J Respir Crit Care Med. 2013 Oct 15;188(8):901-6. DOI:10.1164/rccm.201302-0388PP |
| | Sodium theophylline glycinate Preparation Products And Raw materials |
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