| Company Name: |
Sigma-Aldrich |
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021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Company Name: |
BOC Sciences |
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16314854226 |
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info@bocsci.com |
ERK Inhibitor manufacturers
- ERK-IN-4
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- $40.00
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2026-07-27
- CAS:1049738-54-6
- Purity: 99.95%
- Supply Ability: 10g
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| | ERK Inhibitor Basic information |
| Product Name: | ERK Inhibitor | | Synonyms: | (5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione:hydrochloride;ERK Inhibitor - CAS 1049738-54-6 - Calbiochem;3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,monohydrochloride;ERK-IN-4 | | CAS: | 1049738-54-6 | | MF: | C14H17ClN2O3S | | MW: | 328.82 | | EINECS: | | | Product Categories: | | | Mol File: | 1049738-54-6.mol |  |
| | ERK Inhibitor Chemical Properties |
| storage temp. | +2C to +8C | | solubility | DMSO: 2 mg/ml | | form | Light yellow solid | | color | Off-white to yellow | | InChIKey | PQVLWVGMXJPJLG-UHFFFAOYSA-N | | SMILES | S1C(=O)N(C(=O)C1=Cc2ccc(cc2)OCC)CCN.Cl |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | ERK Inhibitor Usage And Synthesis |
| Description | ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 μM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2. Presumably through its effects on ERK, ERK inhibitor completely prevents proliferation of HeLa cells (IC50 = 15-20 μM), A549 lung carcinoma cells (IC50 = 25 μM), Sum-159 estrogen receptor-negative breast cancer cells and HT1080 fibrosarcoma cells. | | Uses | ERK-IN-4 is an ERK inhibitor binds preferentially to ERK2 with a Kd of 5 μM. ERK-IN-4 specificity inhibits ERK Rsk-1 and Elk-1 phosphorylation. ERK-IN-4 has little effect on ERK protein phosphorylation by its upstream activator MEK1/2[1]. | | General Description | A cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC50 ≤ 25 μM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a KD of ~5 μM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2. | | Biochem/physiol Actions | Primary TargetERK | | IC 50 | ERK2: 5 μM (Kd) | | References | [1] Chad N Hancock, et al. Identification of novel extracellular signal-regulated kinase docking domain inhibitors. J Med Chem. 2005 Jul 14;48(14):4586-95. DOI:10.1021/jm0501174 |
| | ERK Inhibitor Preparation Products And Raw materials |
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