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BOC Sciences |
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Compound 28 manufacturers
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| | Compound 28 Basic information |
| Product Name: | Compound 28 | | Synonyms: | mTOR Inhibitor, WYE-28;WYE-28;1-Piperidinecarboxylic acid, 4-[6-[4-[[[[4-(hydroxymethyl)phenyl]amino]carbonyl]amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-, methyl ester;4-[6-[4-[[[[4-(hydroxymethyl)phenyl]amino]carbonyl]amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylicacid,methylester;Methyl 4-(6-(4-(3-(4-(hydroxymethyl)phenyl)ureido)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate | | CAS: | 1062172-60-4 | | MF: | C30H34N8O5 | | MW: | 586.64 | | EINECS: | | | Product Categories: | | | Mol File: | 1062172-60-4.mol |  |
| | Compound 28 Chemical Properties |
| density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 60 mg/ml | | form | White powder solid. | | pka | 13.98±0.70(Predicted) | | color | White to off-white |
| | Compound 28 Usage And Synthesis |
| Uses | mTOR inhibitor WYE-28 (compound 28) is a selective inhibitor of mTOR>/b< (IC50)=0.08 nM. mTOR inhibitor WYE-28 inhibits PI3Kα with an IC50 value of 6 nM. mTOR inhibitor WYE-28 shows a metabolic time (T1/2) in nude mouse microsomes of 13 min[1]. | | References | [1] Zask A, et al. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6. DOI:10.1021/jm900851f |
| | Compound 28 Preparation Products And Raw materials |
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