| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
- NIH-12848
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- $32.00
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2026-07-27
- CAS:959551-10-1
- Purity: 99.90%
- Supply Ability: 10g
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| | NIH-12848 Basic information |
| Product Name: | NIH-12848 | | Synonyms: | N-(thiophen-2-ylmethyl)-2-(2-(trifluoromethyl)phenyl)quinazolin-4-amine;NIH12848;NIH 12848;NIH-12848, >98%;NIH-12848;NIH-12848, 959551-10-1;4-Quinazolinamine, N-(2-thienylmethyl)-2-[2-(trifluoromethyl)phenyl]-;NIH-12848,NIH12848,Inhibitor,inhibit,NIH 12848;NIH-12848, 10 mM in DMSO | | CAS: | 959551-10-1 | | MF: | C20H14F3N3S | | MW: | 385.41 | | EINECS: | | | Product Categories: | | | Mol File: | 959551-10-1.mol |  |
| | NIH-12848 Chemical Properties |
| Boiling point | 441.6±45.0 °C(Predicted) | | density | 1.384±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 25 mg/mL | | form | A crystalline solid | | pka | 5.05±0.30(Predicted) | | color | White to off-white | | InChI | 1S/C20H14F3N3S/c21-20(22,23)16-9-3-1-7-14(16)19-25-17-10-4-2-8-15(17)18(26-19)24-12-13-6-5-11-27-13/h1-11H,12H2,(H,24,25,26) | | InChIKey | QBDAEJRHUCSSPR-UHFFFAOYSA-N | | SMILES | FC(F)(F)c1c(cccc1)c2nc3c(c(n2)NCc4[s]ccc4)cccc3 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | NIH-12848 Usage And Synthesis |
| Uses | NIH-12848 is a a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor, and also a potentially powerful tool for exploring the cell physiology of PI5P4Ks. Reagent in the synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amines as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer. | | Biological Activity | Cell permeable: yes', 'Primary Target
PI5P4Kγ', 'Reversible: yes |
| | NIH-12848 Preparation Products And Raw materials |
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