| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
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sales8178@energy-chemical.com |
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| | Oxazole-5-carboxylic acid Basic information |
| | Oxazole-5-carboxylic acid Chemical Properties |
| Melting point | 195-197 | | Boiling point | 289.3±13.0 °C(Predicted) | | density | 1.449±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | solid | | pka | 2.39±0.10(Predicted) | | color | Off-white to brown | | Water Solubility | Soluble in water. | | InChI | 1S/C4H3NO3/c6-4(7)3-1-5-2-8-3/h1-2H,(H,6,7) | | InChIKey | QCGMEWVZBGQOFN-UHFFFAOYSA-N | | SMILES | OC(=O)c1cnco1 |
| Hazard Codes | Xi | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 2934999090 | | Storage Class | 13 - Non Combustible Solids |
| | Oxazole-5-carboxylic acid Usage And Synthesis |
| Uses | Decarboxylative cross-coupling of thiazole and oxazole-5-carboxylic acids with aryl halides is reported. | | Synthesis | General procedure for the synthesis of oxazole-5-carboxylic acid from ethyl oxazole-5-carboxylate: an aqueous solution of lithium hydroxide monohydrate (124.5 kg, prepared by dissolving 49.44 kg of lithium hydroxide monohydrate in 319 kg of water, 398 mol) was slowly added to a solution of ethyl oxazole-5-carboxylate (54 kg, 382.7 mol) in water (54 kg), the reaction The temperature was kept below 25°C during the reaction. the reaction mixture was stirred for 6.5 h and then concentrated. Subsequently, an aqueous HCl solution (64.8 kg) was slowly added while keeping the temperature below 25°C. The mixture was cooled to 5°C and maintained for 1 h to promote crystallization. The crystalline product was collected by filtration, washed sequentially with cold water (88 kg) and isopropanol (171 kg) and finally dried under vacuum at 50 °C to give oxazole-5-carboxylic acid (37.88 kg, 87% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 13.68 (br.s, 1H), 8.59 (s, 1H), 7.88 (s, 1H). | | References | [1] Patent: WO2016/193255, 2016, A1. Location in patent: Page/Page column 21
[2] Patent: WO2018/29126, 2018, A1. Location in patent: Page/Page column 49 |
| | Oxazole-5-carboxylic acid Preparation Products And Raw materials |
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