Suzetrigine manufacturers
- SUZETRIGINE
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- $1.00
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2026-09-15
- CAS:2649467-58-1
- Min. Order: 300g
- Purity: 99.8%
- Supply Ability: 20 TONS
- Suzetrigine
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-
2026-09-15
- CAS:2649467-58-1
- Min. Order: 1g
- Purity: More Than 99%
- Supply Ability: 100kg/Month
- Suzetrigine（VX-548）
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2026-09-15
- CAS:2649467-58-1
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 5000kg
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| | Suzetrigine Basic information |
| Product Name: | Suzetrigine | | Synonyms: | 2-Pyridinecarboxamide, 4-[[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]-;Suzetrigine;VX-548（Suzetrigine）;4-[(2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carboxamido]picolinamide;(2R,3S,4S,5R)-4-[[3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carbonyl]amino]pyridine-2-carboxamide;SUZETRIGINE/VAX548;FANDACHEM VX-548;FANDACHEM Suzetrigine | | CAS: | 2649467-58-1 | | MF: | C21H20F5N3O4 | | MW: | 473.4 | | EINECS: | 200-100-8 | | Product Categories: | SUZETRIGINE;API | | Mol File: | 2649467-58-1.mol |  |
| | Suzetrigine Chemical Properties |
| Boiling point | 591.8±50.0 °C(Predicted) | | density | 1.399±0.06 g/cm3(Predicted) | | solubility | Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
DMSO: Sparingly Soluble: 1-10 mg/ml | | form | Solid | | pka | 11.74±0.70(Predicted) | | color | White to light yellow | | InChIKey | XSQUJFKRXZMOKA-KRZZIQMTNA-N | | SMILES | C([C@@H]1O[C@@](C)(C(F)(F)F)[C@@H](C)[C@H]1C1C=CC(F)=C(F)C=1OC)(=O)NC1=CC=NC(C(=O)N)=C1 |&1:1,3,9,11,r| |
| | Suzetrigine Usage And Synthesis |
| Description | Suzetrigine is an inhibitor of voltage-gated sodium channel 1.8 (Nav1.8; IC50 = 0.7 nM for the human channel).1 It is selective for Nav1.8 over a panel of eight additional voltage-gated sodium channels (IC50s = >10,000 nM for all).WARNING This product is not for human or veterinary use. | | Synthesis | The synthesis of Suzetrigine (VX-548) revolves around the highly stereoselective construction of its tetrahydropyran core. A typical synthetic route begins with a chiral starting material (e.g., a chiral epoxide) that undergoes a stereoselective addition reaction with a fluoroaryllithium reagent, introducing a phenyl group and a trifluoromethyl group. Subsequently, a nucleophilic cyclization reaction forms the crucial tetrahydropyran ring, thus determining the correct configuration of the four stereocenters. Subsequent steps involve standard organotransformation reactions, such as cross-coupling reactions (e.g., the Suzuki coupling reaction), to introduce the pyridine moiety, ultimately yielding the final Suzetrigine product via deprotection and salt formation. | | References | [1] JIM JONES. Selective Inhibition of NaV1.8 with VX-548 for Acute Pain.[J]. New England Journal of Medicine, 2023, 389 5: 393-405. DOI: 10.1056/nejmoa2209870 |
| | Suzetrigine Preparation Products And Raw materials |
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