6-Benzothiazolol(7CI,8CI,9CI) manufacturers
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| | 6-Benzothiazolol(7CI,8CI,9CI) Basic information |
| | 6-Benzothiazolol(7CI,8CI,9CI) Chemical Properties |
| Melting point | 185.0 to 189.0 °C | | Boiling point | 311.6±15.0 °C(Predicted) | | density | 1.444±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 8.52±0.40(Predicted) | | color | White to Light yellow |
| | 6-Benzothiazolol(7CI,8CI,9CI) Usage And Synthesis |
| Uses | 6-Hydroxybenzothiazole is a useful research chemical used in the synthesis of aryl trifluoromethyl ethers. | | Synthesis | 6-Hydroxybenzothiazole was synthesized using 2-cyano-6-methoxybenzothiazole as starting material after the following steps: first, the ethyl acetate extract was washed with 1 M NaOH solution (50 mL), followed by acidification of the aqueous phase with 3 M HCl and extraction with ethyl acetate. The extract was evaporated from the solvent at 60 °C to induce complete decarboxylation of the unstable acid 13b. Purification of the product by column chromatography (eluent ratio dichloromethane/acetone 95:5) afforded 6-hydroxybenzothiazole 14 as a colorless solid. Further purification by recrystallization from aqueous ethanol gave 0.7 g (4.6 mmol, 50% yield) of the target product. The melting point of the compound was 190-192 °C (literature value 24: 184-185 °C), and the Rf value for thin layer chromatography was 0.35 (unfolding agent ratio petroleum ether/ethyl acetate 6:4).1H NMR (CD3OD) data were as follows: δ = 8.98 (s, 1H, 2-H), 7.88 (d, J = 8.3 Hz, 1H, 4-H), 7.38 (d, J = 2.1 Hz, 1H, 7-H), 7.06 (dd, J = 8.3 and 2.1 Hz, 1H, 5-H) ppm. 13C NMR (CD3OD) data were as follows: δ = 164.8 (6-C), 155.9 (9-C), 152.1 (2-CH), 134.9 (8-C), 122.8 (4-CH), 115.9 (5 -CH), 106.1 (7-CH) ppm. | | References | [1] Synthesis, 2001, # 12, p. 1780 - 1783
[2] Tetrahedron, 2013, vol. 69, # 29, p. 5893 - 5897 |
| | 6-Benzothiazolol(7CI,8CI,9CI) Preparation Products And Raw materials |
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