Methanone, [2-chloro-3-(trifluoromethyl)phenyl][1,4,6,7-tetrahydro-1-(2-pyrimidinyl)-5H-1,2,3-triazolo[4,5-c]pyridin-5-yl]-

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Methanone, [2-chloro-3-(trifluoromethyl)phenyl][1,4,6,7-tetrahydro-1-(2-pyrimidinyl)-5H-1,2,3-triazolo[4,5-c]pyridin-5-yl]- Suppliers list
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Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

Methanone, [2-chloro-3-(trifluoromethyl)phenyl][1,4,6,7-tetrahydro-1-(2-pyrimidinyl)-5H-1,2,3-triazolo[4,5-c]pyridin-5-yl]- manufacturers
Methanone, [2-chloro-3-(trifluoromethyl)phenyl][1,4,6,7-tetrahydro-1-(2-pyrimidinyl)-5H-1,2,3-triazolo[4,5-c]pyridin-5-yl]- Basic information
Product Name:Methanone, [2-chloro-3-(trifluoromethyl)phenyl][1,4,6,7-tetrahydro-1-(2-pyrimidinyl)-5H-1,2,3-triazolo[4,5-c]pyridin-5-yl]-
Synonyms:Methanone, [2-chloro-3-(trifluoromethyl)phenyl][1,4,6,7-tetrahydro-1-(2-pyrimidinyl)-5H-1,2,3-triazolo[4,5-c]pyridin-5-yl]-;P2X7 receptor antagonist-3
CAS:1627900-92-8
MF:C17H12ClF3N6O
MW:408.77
EINECS:
Product Categories:
Mol File:1627900-92-8.mol
Methanone, [2-chloro-3-(trifluoromethyl)phenyl][1,4,6,7-tetrahydro-1-(2-pyrimidinyl)-5H-1,2,3-triazolo[4,5-c]pyridin-5-yl]- Structure
Methanone, [2-chloro-3-(trifluoromethyl)phenyl][1,4,6,7-tetrahydro-1-(2-pyrimidinyl)-5H-1,2,3-triazolo[4,5-c]pyridin-5-yl]- Chemical Properties
Boiling point 639.5±65.0 °C(Predicted)
density 1.61±0.1 g/cm3(Predicted)
pka-1.49±0.20(Predicted)
Safety Information
MSDS Information
Methanone, [2-chloro-3-(trifluoromethyl)phenyl][1,4,6,7-tetrahydro-1-(2-pyrimidinyl)-5H-1,2,3-triazolo[4,5-c]pyridin-5-yl]- Usage And Synthesis
UsesP2X7 receptor antagonist-3 is a potent P2X7 receptor antagonist with P2X7R IC50 values of 4.2 nM in humans and 6.8 nM in rats[1].
IC 50hP2X7R: 4.2 nM (IC50); rP2X7R: 6.8 nM (IC50)
References[1] Brad M Savall, et al. Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists. ACS Med Chem Lett. 2015 Apr 24;6(6):671-6. DOI:10.1021/acsmedchemlett.5b00089
Methanone, [2-chloro-3-(trifluoromethyl)phenyl][1,4,6,7-tetrahydro-1-(2-pyrimidinyl)-5H-1,2,3-triazolo[4,5-c]pyridin-5-yl]- Preparation Products And Raw materials
Tag:Methanone, [2-chloro-3-(trifluoromethyl)phenyl][1,4,6,7-tetrahydro-1-(2-pyrimidinyl)-5H-1,2,3-triazolo[4,5-c]pyridin-5-yl]-(1627900-92-8) Related Product Information
Methanone, [2-chloro-3-(trifluoromethyl)phenyl][1,4,6,7-tetrahydro-1-(2-pyrimidinyl)-5H-1,2,3-triazolo[4,5-c]pyridin-5-yl]- (r)-(2-chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyrimidin-2-yl)-4-methyl-1,4,6,7-tetrahydro-5h-[1,2,3]triazolo[4,5-c]pyridin-5-yl)methanone Ppads tetrasodium salt 1H-Naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione, 5-[3-(2,5-dihydro-5-thioxo-1,2,4-oxadiazol-3-yl)phenyl]-, sodium salt (1:1) 2'- and 3'-O-(4-Benzoylbenzoyl)-adenosine 5'-triphosphate triethylammonium salt Oxatomide