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| | 2,8-Dibromoquinoline Basic information |
| | 2,8-Dibromoquinoline Chemical Properties |
| Melting point | 118-119 °C | | Boiling point | 349.4±22.0 °C(Predicted) | | density | 1.923±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | -2.16±0.50(Predicted) |
| | 2,8-Dibromoquinoline Usage And Synthesis |
| Synthesis | Step 2C: Preparation of 2,8-dibromoquinoline: 8-bromo-1H-2-quinolinone (5 g, 22 mmol) was mixed with phosphorus tribromide (13 g, 45 mmol), heated to 140 °C and reacted for 3 hours. After completion of the reaction, the mixture was slowly poured into a pre-prepared ice-water mixture (100 g ice with 100 mL water). After continuous stirring for 1 h, the precipitated solid was collected by filtration to afford the target product 2,8-dibromoquinoline (5.1 g, 80% yield). The product was confirmed by mass spectrometry analysis (APCI+ mode), detecting m/z 286, 288, and 290 (corresponding to [M+1]+ peaks for different combinations of bromine isotopes). | | References | [1] Tetrahedron Letters, 2005, vol. 46, # 48, p. 8419 - 8422
[2] Journal of Medicinal Chemistry, 2009, vol. 52, # 3, p. 868 - 877
[3] Patent: WO2008/124323, 2008, A1. Location in patent: Page/Page column 29
[4] Patent: WO2008/121687, 2008, A2. Location in patent: Page/Page column 28
[5] Organometallics, 2018, vol. 37, # 16, p. 2760 - 2768 |
| | 2,8-Dibromoquinoline Preparation Products And Raw materials |
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