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| | 6-Phenylnicotinic acid Basic information |
| | 6-Phenylnicotinic acid Chemical Properties |
| Melting point | 243 °C | | Boiling point | 388.1±30.0 °C(Predicted) | | density | 1.241±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | form | powder to crystal | | pka | 2.19±0.10(Predicted) | | color | White to Light yellow |
| Hazard Note | Harmful | | HS Code | 2933399990 |
| | 6-Phenylnicotinic acid Usage And Synthesis |
| Synthesis Reference(s) | Journal of the American Chemical Society, 99, p. 3166, 1977 DOI: 10.1021/ja00451a053 | | Synthesis | Under argon protection, 6-bromonicotinic acid (1 eq.), phenylboronic acid (1.2 eq.) and tetrakis(triphenylphosphine)palladium (1 mol%) were dissolved in a solvent mixture of dioxane and water (10:1 by volume). Potassium carbonate (2 equivalents) was then added and the reaction mixture was heated to reflux for 6 hours. After completion of the reaction, it was cooled to room temperature and the dioxane was removed by rotary evaporator. Water was added and the pH of the solution was adjusted to 1-3 with 2 N hydrochloric acid. the precipitated white solid precipitate was collected by filtration and dried to give 6-phenylnicotinic acid. | | References | [1] Inorganic Chemistry, 2012, vol. 51, # 4, p. 2105 - 2114
[2] European Journal of Inorganic Chemistry, 2012, # 7, p. 1025 - 1037
[3] Organic Letters, 2016, vol. 18, # 23, p. 6094 - 6097
[4] European Journal of Medicinal Chemistry, 2017, vol. 137, p. 96 - 107 |
| | 6-Phenylnicotinic acid Preparation Products And Raw materials |
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