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| | 3-Bromo-4-fluorobenzaldehyde Basic information |
| | 3-Bromo-4-fluorobenzaldehyde Chemical Properties |
| Melting point | 31-33 °C (lit.) | | Boiling point | 138-139 °C/2.5 mmHg (lit.) | | density | 1.6698 (rough estimate) | | refractive index | 1.574 | | Fp | >230 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | Low Melting Solid | | color | White to light yellow | | Water Solubility | INSOLUBLE | | Sensitive | Air Sensitive | | BRN | 5806226 | | InChI | InChI=1S/C7H4BrFO/c8-6-3-5(4-10)1-2-7(6)9/h1-4H | | InChIKey | FAHZIKXYYRGSHF-UHFFFAOYSA-N | | SMILES | C(=O)C1=CC=C(F)C(Br)=C1 | | CAS DataBase Reference | 77771-02-9(CAS DataBase Reference) | | EPA Substance Registry System | Benzaldehyde, 3-bromo-4-fluoro- (77771-02-9) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36/37/38 | | Safety Statements | 26-36-37/39 | | WGK Germany | 2 | | TSCA | TSCA listed | | HazardClass | IRRITANT | | HS Code | 29130000 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 3-Bromo-4-fluorobenzaldehyde Usage And Synthesis |
| Chemical Properties | white to light yellow low melting solid | | Uses | 3-Bromo-4-fluorobenzaldehyde can be used for pest control. | | Uses | 3-Bromo-4-fluorobenzaldehyde was used in the synthesis of 4-fluoro-3-phenoxybenzoic acid-glycine. It was also used in the synthesis of Schiff bases of 4-nitroaniline/ 2,4-dinitroaniline/3,4-dichloroaniline/4-methoxy-3-nitro aniline via ultrasound irradiation method. | | Synthesis |
A synthetic method of 3-bromo-4-fluorobenzaldehyde comprises the following steps: (1) dissolving 4-fluorobenzaldehyde in dichloromethane to obtain a solution A; (2) dissolving sodium bromide in pure water and adding 35% hydrochloric acid while stirring to obtain a solution B; (3) mixing the solution A and the solution B, starting ultrasonic waves, and dropwise adding a sodium hypochlorite aqueous solution under stirring; (4) after the dripping is finished, carrying out ultrasonic treatment, keeping the temperature under stirring, and then standing; (5) phase separation, washing dichloromethane phase to neutrality, drying and desolventizing; (6) obtaining a crude product, and carrying out bulk melting crystallization at 31 ℃ to obtain a pure product.
| | References | [1] Patent: WO2010/86877, 2010, A2. Location in patent: Page/Page column 11-12
[2] Patent: US5225607, 1993, A
[3] Patent: US4791139, 1988, A
[4] Patent: US4792563, 1988, A
[5] Patent: EP240121, 1991, B1 |
| | 3-Bromo-4-fluorobenzaldehyde Preparation Products And Raw materials |
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