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| | 3-Methyl-1,3-thiazolane-2,4-dione Basic information |
| | 3-Methyl-1,3-thiazolane-2,4-dione Chemical Properties |
| Melting point | 40-43°C | | Boiling point | 130-131 °C(Press: 14 Torr) | | density | 1.421±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | -2.27±0.20(Predicted) | | Appearance | White to off-white Solid | | InChI | InChI=1S/C4H5NO2S/c1-5-3(6)2-8-4(5)7/h2H2,1H3 | | InChIKey | HMLWNNMYODLLJO-UHFFFAOYSA-N | | SMILES | S1CC(=O)N(C)C1=O |
| HazardClass | IRRITANT | | HS Code | 2934999090 |
| | 3-Methyl-1,3-thiazolane-2,4-dione Usage And Synthesis |
| Uses | 3-methyl-1,3-thiazolidine-2,4-dione can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | | Synthesis | 
To a solution of 2,4-thiazolidinedione (1 equiv) in 5 mL of DMF was added potassium carbonate (1.1 equiv) and halogen (1.1 equiv). The suspension was stirred at 80 oC overnight. Solvent was evaporated and the residue was purified by flash column chromatography ( petroleum ether/EtOAc, 5:1) to afford the product 3. 3-Methylthiazolidine-2,4-dione (3a) Following the previous procedure, 2,4-thiazolidinedione (500 mg, 4.3 mmol) and iodomethane (0.3 mL, 4.7 mmol). 3a as white solid (460 mg, 82%). | | References | [1] Journal of Chemical Research, 2005, # 8, p. 492 - 494
[2] Organic and Biomolecular Chemistry, 2011, vol. 9, # 10, p. 3801 - 3807
[3] Organic Letters, 2015, vol. 17, # 6, p. 1361 - 1364
[4] Patent: WO2012/137181, 2012, A1. Location in patent: Page/Page column 136-137
[5] Patent: WO2017/176812, 2017, A1. Location in patent: Paragraph 0503 |
| | 3-Methyl-1,3-thiazolane-2,4-dione Preparation Products And Raw materials |
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