tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate

tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate Suppliers list

Company Name:	Shanghai Boc Chemical Co., Ltd.
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Products Intro:	Product Name:(R)-1-Boc-2-methyl-piperazine CAS:1226781-82-3 Purity:0.99 Package:1000KG；100KG;10KG

Company Name:	ATK CHEMICAL COMPANY LIMITED
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Products Intro:	CAS:1226781-82-3 Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G

Company Name:	career henan chemical co
Tel:	+86-0371-86658258 +8613203830695
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Products Intro:	Product Name:tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate CAS:1226781-82-3 Purity:>=98% Package:1KG;1USD

Company Name:	Hangzhou Cyanochem Co., Ltd.
Tel:	+86 17788583750
Email:	sales@cyanochem.com
Products Intro:	Product Name:Omarigliptin Intermediate 3 CAS:1226781-82-3 Purity:98% Package:100g;300g;1KG,5KG;25KG

Company Name:	Shanghai Yingrui Biopharma Co.,Ltd
Tel:	21-33585366
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Products Intro:	Product Name:tert-butyl 2-(Methylsulfonyl)-4,6 -dihydropyrrolo[3,4-c]pyrazole- 5(2H)-carboxylate Purity:0.99 Package:1kg 5kg 10kg 25kg kilograms per barrel

tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate manufacturers

tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
$0.00/ kg
2024-11-26
CAS:1226781-82-3
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton

tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
$1.00 / 1KG
2019-09-02
CAS:1226781-82-3
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 200kg

tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate Basic information

Product Name:	tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
Synonyms:	tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate;2-(Methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylic acid tert-butyl ester;tert-butyl 2-methanesulfonyl-2H,4H,5H,6H-pyrrolo[3,4-c]pyrazole-5-carboxylate;Omarigliptin Impurity 10;MK-3103 Intermediate IV;tert-butyl 2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylate;Pyrrolo[3,4-c]pyrazole, 2,4,5,6-tetrahydro-2-(methylsulfonyl)-, benzenesulfonate;Omarigliptin Intermediate 3
CAS:	1226781-82-3
MF:	C11H17N3O4S
MW:	287.34
EINECS:
Product Categories:	Omarigliptin intermediate
Mol File:	1226781-82-3.mol

tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate Chemical Properties

Boiling point	441.1±55.0 °C(Predicted)
density	1.40±0.1 g/cm3(Predicted)
storage temp.	2-8°C
pka	-1.95±0.20(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1S/C11H17N3O4S/c1-11(2,3)18-10(15)13-5-8-6-14(19(4,16)17)12-9(8)7-13/h6H,5,7H2,1-4H3
InChIKey	SNEHALFDVXIDSZ-UHFFFAOYSA-N
SMILES	N1(S(C)(=O)=O)C=C2CN(C(OC(C)(C)C)=O)CC2=N1

Safety Information

MSDS Information

tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate Usage And Synthesis

Chemical Properties	white solid
Uses	Tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate is an important organic reagent that can be used as a building block for the synthesis of many organic compounds, such as 2-(methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole. It is an important intermediate of Omarigliptin.
Synthesis	Tert-butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate (3.5 g, 16.7 mmol) was dissolved in tetrahydrofuran (35 ml), and sodium hydride (1.0 g, 60%, 25.4 mmol) was added at 0°C, followed by reaction for 30 min. Methylsulfonyl chloride (2.9 g, 25.4 mmol) was added, followed by a reaction for 1 hour. The reaction was quenched by the addition of water (10 ml) to the reaction solution, which was extracted with ethyl acetate (50 ml*2). The organic layers were combined, dried over anhydrous sodium sulfate, concentrated, and purified by silica gel column chromatography (petroleum ether/ethyl acetate (v/v) = 1:1), to obtain tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate (2.1 g, yield 44%).
References	[1] Patent: EP3159344, 2017, A1. Location in patent: Paragraph 0096; 0132; 0133 [2] Patent: TW2017/8222, 2017, A. Location in patent: Page/Page column 54; 55 [3] Patent: TW2017/8223, 2017, A. Location in patent: Page/Page column 43 [4] Patent: WO2011/103256, 2011, A1. Location in patent: Page/Page column 55 [5] Patent: WO2011/146358, 2011, A1. Location in patent: Page/Page column 61

tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

Tag:tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate(1226781-82-3) Related Product Information

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