6-Hydroxy buspirone

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6-Hydroxy buspirone Basic information
Product Name:6-Hydroxy buspirone
Synonyms:6-Hydroxy-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9- dione;BMY 28674;BMS 528215;Buspirone 6-Hydroxy Metabolite;Buspirone Impurity 17;8-Azaspiro[4.5]decane-7,9-dione, 6-hydroxy-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-;6’-Hydroxy Buspirone;6-Hydroxy Buspirone solution
CAS:125481-61-0
MF:C21H31N5O3
MW:401.5
EINECS:
Product Categories:Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File:125481-61-0.mol
6-Hydroxy buspirone Structure
6-Hydroxy buspirone Chemical Properties
Melting point 96-99°C
storage temp. -20°C Freezer
solubility Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form Solid
color White to Off-White
InChI1S/C21H31N5O3/c27-17-16-21(6-1-2-7-21)18(28)19(29)26(17)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9,18,28H,1-4,6-7,10-16H2
InChIKeyKOZNAHJIJGCFJJ-UHFFFAOYSA-N
SMILESO=C1C(O)C2(CCCC2)CC(N1CCCCN(CC3)CCN3C4=NC=CC=N4)=O
Safety Information
WGK Germany WGK 2
Storage Class3 - Flammable liquids
Hazard ClassificationsAcute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 2
MSDS Information
6-Hydroxy buspirone Usage And Synthesis
Chemical PropertiesOff-White to Pale Yellow Solid
UsesIt is a major active metabolite of Buspirone (B689850).
DefinitionChEBI: 6-hydroxy buspirone is a N-arylpiperazine.
IC 50Rat 5-HT1A Receptor: 4 μM (EC50); D2 Receptor: 3.1 μM (IC50); D3 Receptor: 4.9 μM (IC50); D4 Receptor: 0.85 μM (IC50); Rat 5-HT1A Receptor: 1 μM (EC50)
6-Hydroxy buspirone Preparation Products And Raw materials
Tag:6-Hydroxy buspirone(125481-61-0) Related Product Information
Buspirone hydrochloride 2-(1-Piperazinyl)pyrimidine 3,3-Tetramethyleneglutarimide 5-Hydroxy Buspirone 8,8'-(1,4-Butanediyl)bis-8-azaspiro[4.5]decane-7,9-dione Buspirone EP Impurity E Buspirone EP Impurity B 8-(4-Chlorobutyl)-8-azaspiro[4.5]decane-7,9-dione Buspirone EP Impurity C 2,2'-(1,4-Piperazinediyl)bis-pyrimidine Buspirone EP Impurity M Buspirone N-Oxide Buspirone 3-hydroxypiperidin-2-one Gepirone (R)-5-Hydroxy-piperidin-2-one 6-Hydroxy buspirone