Dde Biotin-PEG4-Alkyne manufacturers
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| | Dde Biotin-PEG4-Alkyne Basic information |
| Product Name: | Dde Biotin-PEG4-Alkyne | | Synonyms: | Biotin-peg(4)-dde-alkyne;Dde Biotin-PEG4-Alkyne;1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[15-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3,6,9,12-tetraoxa-16-azanonadec-18-yn-1-yl]hexahydro-2-oxo-, (3aR,4R,6aS)-rel-;Dde Biotin-PEG4-alkyne Dde | | CAS: | 1802908-00-4 | | MF: | C32H50N4O8S | | MW: | 650.83 | | EINECS: | | | Product Categories: | | | Mol File: | 1802908-00-4.mol |  |
| | Dde Biotin-PEG4-Alkyne Chemical Properties |
| Boiling point | 880.0±65.0 °C(Predicted) | | density | 1.173±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | form | Solid | | pka | 13.90±0.40(Predicted) | | color | Brown to reddish brown |
| | Dde Biotin-PEG4-Alkyne Usage And Synthesis |
| Description | Dde Biotin-PEG4-alkyne is useful for introducing a biotin moiety to azide-containing molecules using Cu(I)-catalyzed Click Chemistry. The hydrophilic spacer arm provides better solubility to the labeled molecules in aqueous media. Dde protecting group allows efficient release of captured biotinylated molecules from streptavidin under mild conditions with hydrazine. | | Uses | Dde Biotin-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Dde Biotin-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Dde Biotin-PEG4-Alkyne Preparation Products And Raw materials |
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