Methyltetrazine-PEG4-Amine manufacturers
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| | Methyltetrazine-PEG4-Amine Basic information |
| Product Name: | Methyltetrazine-PEG4-Amine | | Synonyms: | Methyltetrazine-PEG4-Amine;Ethanamine, 2-[2-[2-[2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy]ethoxy]ethoxy]-;2-(2-(2-(2-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy)ethoxy)ethoxy)ethoxy)ethanamine;3-[4-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethoxy)phenyl]-6-methyl-1,2,4,5-tetrazine;Methyltetrazine-PEG4-Amine (CCT-1012);Methyltetrazine-O-PEG4-amine;Methyltetrazine-PEG4-NH2;Methyltetrazine-PEG4-amine HCl salt | | CAS: | 1802908-05-9 | | MF: | C17H25N5O4 | | MW: | 363.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1802908-05-9.mol |  |
| | Methyltetrazine-PEG4-Amine Chemical Properties |
| Boiling point | 558.7±60.0 °C(Predicted) | | density | 1.186±0.06 g/cm3(Predicted) | | solubility | Soluble in Water, DMSO, DMF, DCM | | pka | 8.74±0.10(Predicted) |
| | Methyltetrazine-PEG4-Amine Usage And Synthesis |
| Description | Methyltetrazine-PEG4-amine is an aqueous soluble PEGylation reagent containing a free amine and a methyltetrazine group. Methyl group improves the stability and hydrophilic PEG spacer increases water-solubility. Methyltetrazine enable fast click reaction with TCO (trans-cycloctene). | | Uses | Methyltetrazine-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Methyltetrazine-PEG4-Amine Preparation Products And Raw materials |
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