Methyltetrazine-PEG5-Alkyne manufacturers
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| | Methyltetrazine-PEG5-Alkyne Basic information |
| Product Name: | Methyltetrazine-PEG5-Alkyne | | Synonyms: | Methyltetrazine-PEG5-Alkyne;1,2,4,5-Tetrazine, 3-methyl-6-[4-(3,6,9,12-tetraoxapentadec-14-yn-1-yloxy)phenyl]-;3-(4-(3,6,9,12-Tetraoxapentadec-14-yn-1-yloxy)phenyl)-6-methyl-1,2,4,5-tetrazine;Methyltetrazine-PEG4-Propargyl | | CAS: | 1802907-97-6 | | MF: | C20H26N4O5 | | MW: | 402.44 | | EINECS: | | | Product Categories: | | | Mol File: | 1802907-97-6.mol |  |
| | Methyltetrazine-PEG5-Alkyne Chemical Properties |
| Boiling point | 568.5±60.0 °C(Predicted) | | density | 1.176±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C, stored under nitrogen | | solubility | Soluble in DMSO, DCM, DMF | | pka | 1.67±0.10(Predicted) | | form | Solid | | color | Pink to red |
| | Methyltetrazine-PEG5-Alkyne Usage And Synthesis |
| Description | Methyltetrazine-PEG5-alkyne is a click chemistry bifunctional molecule containing an alkyne group and a hydrophilic PEG spacer which increases water-solubility. This reagent enables simple and efficient incorporation of a tetrazine moiety onto TCO-attached antibodies, peptide or other biomolecule The alkynes can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. | | Uses | Methyltetrazine-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Methyltetrazine-PEG5-Alkyne Preparation Products And Raw materials |
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