- Fmoc-NMe-PEG3-acid
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2025-06-07
- CAS:1807518-77-9
- Min. Order: 500mg
- Purity: >98.00%
- Supply Ability: 500mg
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| | Fmoc-N-methyl-N-amido-PEG2-acid Basic information |
| Product Name: | Fmoc-N-methyl-N-amido-PEG2-acid | | Synonyms: | Fmoc-N-methyl-N-amido-PEG2-acid;Fmoc-N-methyl-N-amido-PEG2-COOH;Fmoc-NMe-PEG2-acid;Fmoc-N-methyl-PEG3-CH2CH2COOH;5,8,11-Trioxa-2-azatetradecanedioic acid, 2-methyl-, 1-(9H-fluoren-9-ylmethyl) ester;Fmoc-NMe-PEG3-acid;Fmoc-MeN-PEG3-CH2CH2COOH;Fmoc-N-Me-PEG3-CH2CH2COOH | | CAS: | 1807518-77-9 | | MF: | C25H31NO7 | | MW: | 457.52 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1807518-77-9.mol |  |
| | Fmoc-N-methyl-N-amido-PEG2-acid Chemical Properties |
| Boiling point | 630.5±55.0 °C(Predicted) | | density | 1.218±0.06 g/cm3(Predicted) | | solubility | Soluble in DMSO, DCM, DMF | | pka | 4.28±0.10(Predicted) |
| | Fmoc-N-methyl-N-amido-PEG2-acid Usage And Synthesis |
| Description | Fmoc-N-methyl-N-amido-PEG2-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | | Uses | Fmoc-N-methyl-PEG3-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-N-methyl-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | Cleavable Linker; Alkyl/ether; PEGs | | References | [1] Yang Y,et al. Design, synthesis, and biological characterization of novel PEG-linked dimeric modulators for CXCR4. Bioorg Med Chem. 2016 Nov 1;24(21):5393-5399. DOI:10.1016/j.bmc.2016.08.062 |
| | Fmoc-N-methyl-N-amido-PEG2-acid Preparation Products And Raw materials |
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