- Propargyl-PEG1-COOtBu
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2026-07-24
- CAS:488150-84-1
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
- Propargyl-PEG1-Boc
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2026-07-14
- CAS:488150-84-1
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 20Tons
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| | Propargyl-PEG1-t-butyl ester Basic information |
| Product Name: | Propargyl-PEG1-t-butyl ester | | Synonyms: | Propargyl-PEG1-t-butyl ester;Alkyne-PEG1-CH2CH2COOtBu;PROPARGYL-PEG1-CH2CH2COOTBU;3-(2-Propyn-1-yloxy)propanoic acid tert-butyl ester;Propargyl-PEG1-COOtBu;Propargyl-PEG1-Boc;Propanoic acid, 3-(2-propyn-1-yloxy)-, 1,1-dimethylethyl ester;tert-butyl 3-prop-2-ynoxypropanoate | | CAS: | 488150-84-1 | | MF: | C10H16O3 | | MW: | 184.23 | | EINECS: | | | Product Categories: | peg | | Mol File: | 488150-84-1.mol |  |
| | Propargyl-PEG1-t-butyl ester Chemical Properties |
| storage temp. | Storage temp. 2-8°C | | form | Liquid | | color | Colorless to light yellow | | InChI | InChI=1S/C10H16O3/c1-5-7-12-8-6-9(11)13-10(2,3)4/h1H,6-8H2,2-4H3 | | InChIKey | VDHVLESCKRSEAF-UHFFFAOYSA-N | | SMILES | C(OC(C)(C)C)(=O)CCOCC#C |
| | Propargyl-PEG1-t-butyl ester Usage And Synthesis |
| Description | Propargyl-PEG1-t-butyl ester has a propargyl group and a t-butyl protected carboxyl group. The propargyl group can participate in copper catalyzed azide-alkyne Click Chemistry to form a stable triazole linkage. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Uses | Propargyl-PEG1-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG1-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Propargyl-PEG1-t-butyl ester Preparation Products And Raw materials |
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