Propargyl-PEG1-SS-PEG1-propargyl manufacturers
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| | Propargyl-PEG1-SS-PEG1-propargyl Basic information |
| | Propargyl-PEG1-SS-PEG1-propargyl Chemical Properties |
| Boiling point | 326.0±37.0 °C(Predicted) | | density | 1.141±0.06 g/cm3(Predicted) |
| | Propargyl-PEG1-SS-PEG1-propargyl Usage And Synthesis |
| Description | Propargyl-PEG1-SS-PEG1-propargyl is a homoebifunctional cleavable PEG linker containing two propargyl groups and a disulfide bond. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. Disulfide bond cn be cleaved with reducing agent. | | Uses | Propargyl-PEG1-SS-PEG1-propargyl is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG1-SS-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | Disulfide Cleavable Linker; Cleavable Linker | | References | [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
| | Propargyl-PEG1-SS-PEG1-propargyl Preparation Products And Raw materials |
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