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- Propargyl-PEG3-N3
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-
2025-06-07
- CAS:932741-18-9
- Min. Order: 1g
- Purity: >98.00%
- Supply Ability: 1g
- Propargyl-PEG3-azide
-
- $1800.00
-
2024-02-13
- CAS:932741-18-9
- Min. Order: 1g
- Purity: 95
- Supply Ability: 1 Kg
|
| | Propargyl-PEG3-azide Basic information |
| Product Name: | Propargyl-PEG3-azide | | Synonyms: | Azido-PEG3-propargyl;Propargyl-PEG3-azide;HC≡C-CH2-PEG3-NH2;Alkyne-PEG3-NH2;PROPARGYL-PEG3-NH2;3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)prop-1-yne;1-Propyne, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-;NH2-PEG3-Alkyne | | CAS: | 932741-18-9 | | MF: | C9H15N3O3 | | MW: | 213.24 | | EINECS: | | | Product Categories: | peg | | Mol File: | 932741-18-9.mol |  |
| | Propargyl-PEG3-azide Chemical Properties |
| | Propargyl-PEG3-azide Usage And Synthesis |
| Uses | Propargyl-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | Biological Activity | Propargyl-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | IC 50 | PEGs | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | Propargyl-PEG3-azide Preparation Products And Raw materials |
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