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- 2-Chloronicotinamide
-
- $1.10
-
2026-08-20
- CAS:10366-35-5
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
- 2-Chloronicotinamide
-
- $10.00
-
2021-10-15
- CAS:10366-35-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20 Tons
|
| | 2-Chloronicotinamide Basic information |
| | 2-Chloronicotinamide Chemical Properties |
| Melting point | 164-167 °C(lit.) | | Boiling point | 313.7±27.0 °C(Predicted) | | density | 1.4411 (rough estimate) | | refractive index | 1.5400 (estimate) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 14.19±0.50(Predicted) | | form | Fine Crystalline Powder | | color | Beige | | BRN | 119026 | | InChI | InChI=1S/C6H5ClN2O/c7-5-4(6(8)10)2-1-3-9-5/h1-3H,(H2,8,10) | | InChIKey | ZQZAHPFFZWEUCL-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC=CC=C1C(N)=O | | CAS DataBase Reference | 10366-35-5(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29333990 |
| | 2-Chloronicotinamide Usage And Synthesis |
| Chemical Properties | BEIGE FINE CRYSTALLINE POWDER | | Uses | 2-Chloronicotinamide is an off-white gracile crystal powder and serves as an important drug intermediate. 2-Chloronicotinamide acts as a substrate and precursor to produce 2-chloronicotinic acid through amidase-mediated hydrolysis and biocatalytic processes. 2-Chloronicotinamide is applied as a precursor in the synthesis of 2-piperazin-1-ylnicotinamide, 2-chloropyridine-3-carbothioamide, and 2-chloro-N-iso-butylnicotinamide[6-8]. | | Synthesis | General procedure for the synthesis of 2-chloronicotinamide from 2-chloro-3-cyanopyridine: 400 mL of concentrated sulfuric acid was added to a 1000 mL three-necked flask, followed by the addition of 2-chloro-3-cyanopyridine (138 g, 1 mol), which was stirred until completely dissolved. The reaction system was warmed up to 90 °C and the reaction was maintained at this temperature with stirring for 2 hours. Upon completion of the reaction, the reaction mixture was slowly poured into a mixture containing 1000 mL of ammonia and 1 kg of ice and stirring was continued for 1 hour. The precipitated crude product was collected by filtration. The crude product was transferred to 1000 mL of ethyl acetate and stirred for 1 hour to wash and subsequently separated by filtration to give a white solid product. Finally, the white solid was dried by blowing at 50 °C to give 153 g of the intermediate 2-chloronicotinamide as a white solid in 98% yield. | | References | [1] Patent: CN105367571, 2017, B. Location in patent: Paragraph 0014; 0037; 0038
[2] Tetrahedron Letters, 2012, vol. 53, # 4, p. 449 - 452
[3] Journal of Chemical Research, 2011, vol. 35, # 8, p. 480 - 483
[4] Synlett, 2018, vol. 29, # 15, p. 2061 - 2065
[5] Journal of Organic Chemistry, 1954, vol. 19, p. 1633,1636
[6]
Tang, X.-L., Jin, J.-Q., Wu, Z.-M., Jin, L.-Q., Zheng, R.-C., Zheng, Y.-G. (2019). Structure-Based Engineering of Amidase from Pantoea sp. for Efficient 2-Chloronicotinic Acid Biosynthesis. Applied and Environmental Microbiology, 85(5). https://doi.org/10.1128/aem.02471-18
[7]
Zheng, R.-C., Jin, J.-Q., Wu, Z.-M., Tang, X.-L., Jin, L.-Q., Zheng, Y.-G. (2018). Biocatalytic hydrolysis of chlorinated nicotinamides by a superior AS family amidase and its application in enzymatic production of 2-chloronicotinic acid. Bioorganic Chemistry, 76, 81–87. https://doi.org/10.1016/j.bioorg.2017.11.001
[8]
He, H., Zhang, J., Niu, X., Wan, B., Lv, M., Li, F., Gao, X., Wan, Y., Yu, Y. (2025). Solubility determination, molecular simulation and thermodynamic analysis of 2-chloronicotinamide in three binary solvents from 278.15 K to 328.15 K. Journal of Molecular Liquids, 422, 126929. https://doi.org/10.1016/j.molliq.2025.126929
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| | 2-Chloronicotinamide Preparation Products And Raw materials |
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