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| | N-(Boc-PEG3)-N-Bis-(PEG2-alcohol) Basic information |
| Product Name: | N-(Boc-PEG3)-N-Bis-(PEG2-alcohol) | | Synonyms: | N-(Boc-PEG3)-N-Bis-(PEG2-alcohol);5,8,11,17,20-Pentaoxa-2,14-diazadocosanoic acid, 22-hydroxy-14-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]-, 1,1-dimethylethyl ester;N-(NHBoc-PEG3)-N-bis(PEG2-alcohol) | | CAS: | 2055042-60-7 | | MF: | C25H52N2O11 | | MW: | 556.69 | | EINECS: | | | Product Categories: | | | Mol File: | 2055042-60-7.mol |  |
| | N-(Boc-PEG3)-N-Bis-(PEG2-alcohol) Chemical Properties |
| Boiling point | 638.8±55.0 °C(Predicted) | | density | 1.112±0.06 g/cm3(Predicted) | | solubility | Soluble in Water, DMSO, DCM, DMF | | pka | 12.23±0.46(Predicted) |
| | N-(Boc-PEG3)-N-Bis-(PEG2-alcohol) Usage And Synthesis |
| Description | N-(Boc-PEG3)-N-bis(PEG2-alcohol) is a branched PEG linker with a Boc protecting group and two PEG2-alcohol branches connected to a central nitrogen. The Boc can be removed under acidic conditions. The hydroxyl groups can react the further derivatize the compound. The hydrophilic PEG linkers increase the water solubility of the compound. Branched PEG linkers have increased conjugation efficiency. | | Uses | N-(Boc-PEG3)-N-bis(PEG2-alcohol) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-(Boc-PEG3)-N-Bis-(PEG2-alcohol) Preparation Products And Raw materials |
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