N-(Boc-PEG1)-N-bis(PEG2-propargyl) manufacturers
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| | N-(Boc-PEG1)-N-bis(PEG2-propargyl) Basic information |
| Product Name: | N-(Boc-PEG1)-N-bis(PEG2-propargyl) | | Synonyms: | N-(Boc-PEG1)-N-bis(PEG2-propargyl);5,11,14-Trioxa-2,8-diazaheptadec-16-ynoic acid, 8-[2-[2-(2-propyn-1-yloxy)ethoxy]ethyl]-, 1,1-dimethylethyl ester;N-(NHBoc-PEG1)-N-bis(PEG2-propargyl) | | CAS: | 2100306-63-4 | | MF: | C23H40N2O7 | | MW: | 456.57 | | EINECS: | | | Product Categories: | | | Mol File: | 2100306-63-4.mol |  |
| | N-(Boc-PEG1)-N-bis(PEG2-propargyl) Chemical Properties |
| Boiling point | 535.4±50.0 °C(Predicted) | | density | 1.068±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C, protect from light | | form | Viscous Liquid | | pka | 12.26±0.46(Predicted) | | color | Colorless to light yellow |
| | N-(Boc-PEG1)-N-bis(PEG2-propargyl) Usage And Synthesis |
| Description | N-(Boc-PEG1)-N-bis(PEG2-propargyl) is a click chemistry branched linker. The propargyl groups can react with azide-bearing molecule via copper catalyzed Click Chemistry . The Boc group can be deprotected under acidic conditions to release amine group. | | Uses | N-(Boc-PEG1)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Boc-PEG1)-N-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-(Boc-PEG1)-N-bis(PEG2-propargyl) Preparation Products And Raw materials |
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