(5Z)-6A-CARBAPROSTAGLANDIN I2 manufacturers
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| | (5Z)-6A-CARBAPROSTAGLANDIN I2 Basic information |
| Product Name: | (5Z)-6A-CARBAPROSTAGLANDIN I2 | | Synonyms: | 6,9ALPHA-METHYLENE-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID;(5Z)-6A-CARBAPROSTAGLANDIN I2;Pentanoic acid, 5-[(3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-1-octenyl]-2(1H)-pentalenylidene]-, (5Z)- (9CI);5 cis Carbaprostacyclin,5cis Carbaprostacyclin;5-CIS CARBAPROSTACYCLIN | | CAS: | 69609-77-4 | | MF: | C21H34O4 | | MW: | 350.49 | | EINECS: | | | Product Categories: | | | Mol File: | 69609-77-4.mol |  |
| | (5Z)-6A-CARBAPROSTAGLANDIN I2 Chemical Properties |
| Boiling point | 514.8±50.0 °C(Predicted) | | density | 1.177±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: >10 mg/ml (from 6B-PGI2); DMSO: >5 mg/ml (from 6B-PGI2); Ethanol: >20 mg/ml (from 6B-PGI2); PBS pH 7.2: >80 μg/ml (from 6B-PGI2) | | form | A crystalline solid | | pka | 4.77±0.10(Predicted) |
| | (5Z)-6A-CARBAPROSTAGLANDIN I2 Usage And Synthesis |
| Uses | 5-cis Carbaprostacyclin is a stable analog of PGI2 based on Carbaprostacyclin (HY-112322). Carbacyclin is a PGI2 receptor agonist and vasodilator that activates PPARδ. 5-cis Carbaprostacyclin induces relaxation of pulmonary vascular tone[1][2]. | | Definition | ChEBI: Carbacyclin is a prostanoid. | | References | [1] Kurtz M, et al. Carbaprostacyclin, a PPARdelta agonist, ameliorates excess lipid accumulation in diabetic rat placentas. Life Sci. 2010 May 22;86(21-22):781-90. DOI:10.1016/j.lfs.2010.03.008
[2] Norel X, et al. Vasoconstriction induced by activation of EP1 and EP3 receptors in human lung: effects of ONO-AE-248, ONO-DI-004, ONO-8711 or ONO-8713. Prostaglandins Other Lipid Mediat. 2004 Oct;74(1-4):101-12. DOI:10.1016/j.prostaglandins.2004.07.003 |
| | (5Z)-6A-CARBAPROSTAGLANDIN I2 Preparation Products And Raw materials |
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