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| | Azido-PEG3-methyl ester Basic information |
| Product Name: | Azido-PEG3-methyl ester | | Synonyms: | Azido-PEG3-methyl ester;methyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate;N3-PEG3-COOMe;Methyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate , Azido-PEG3-methyl ester | | CAS: | 2086689-07-6 | | MF: | C10H19N3O5 | | MW: | 261.28 | | EINECS: | | | Product Categories: | | | Mol File: | 2086689-07-6.mol |  |
| | Azido-PEG3-methyl ester Chemical Properties |
| | Azido-PEG3-methyl ester Usage And Synthesis |
| Description | Azido-PEG3-methyl ester is a click chemistry reagent with an azide(N3) and methyl ester moieties. The azide group can react with alkynes in copper-free Click Chemistry reactions. Methyl ester can be hydrolyzed under strong basic condition. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media. | | Uses | Azido-PEG3-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-methyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Azido-PEG3-methyl ester Preparation Products And Raw materials |
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