N-(Acid-PEG2)-N-bis(PEG2-propargyl)

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N-(Acid-PEG2)-N-bis(PEG2-propargyl) Basic information
Product Name:N-(Acid-PEG2)-N-bis(PEG2-propargyl)
Synonyms:N-(Acid-PEG2)-N-bis(PEG2-propargyl);N-(PEG2-C2-acid)-N-bis(PEG2-propargyl);4,7,13,16-Tetraoxa-10-azanonadec-18-ynoic acid, 10-[2-[2-(2-propyn-1-yloxy)ethoxy]ethyl]-
CAS:2100306-49-6
MF:C21H35NO8
MW:429.5
EINECS:
Product Categories:
Mol File:2100306-49-6.mol
N-(Acid-PEG2)-N-bis(PEG2-propargyl) Structure
N-(Acid-PEG2)-N-bis(PEG2-propargyl) Chemical Properties
Boiling point 533.6±50.0 °C(Predicted)
density 1.122±0.06 g/cm3(Predicted)
solubility Soluble in Water, DMSO, DCM, DMF
pka4.27±0.10(Predicted)
Safety Information
MSDS Information
N-(Acid-PEG2)-N-bis(PEG2-propargyl) Usage And Synthesis
DescriptionN-(Acid-PEG2)-N-bis(PEG2-propargyl) is reactive with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amino groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
UsesN-(PEG2-C2-acid)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(PEG2-C2-acid)-N-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50PEGs
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
N-(Acid-PEG2)-N-bis(PEG2-propargyl) Preparation Products And Raw materials
Tag:N-(Acid-PEG2)-N-bis(PEG2-propargyl)(2100306-49-6) Related Product Information
N-(t-butyl ester-PEG2)-N-bis(PEG2-propargyl) Tri(carboxyethyloxyethyl)amine HCl salt N-Me-N-(PEG4-acid)2 N-(Amino-PEG5)-N-bis(PEG4-acid) N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt N-(acid-PEG3)-N-bis(PEG3-amine)