N-(t-butyl ester-PEG2)-N-bis(PEG2-propargyl) manufacturers
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| | N-(t-butyl ester-PEG2)-N-bis(PEG2-propargyl) Basic information |
| | N-(t-butyl ester-PEG2)-N-bis(PEG2-propargyl) Chemical Properties |
| Boiling point | 531.2±45.0 °C(Predicted) | | density | 1.060±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C, protect from light | | form | Viscous Liquid | | pka | 6.88±0.50(Predicted) | | color | Yellow to brown |
| | N-(t-butyl ester-PEG2)-N-bis(PEG2-propargyl) Usage And Synthesis |
| Description | N-(t-butyl ester-PEG2)-N-bis(PEG2-propargyl) is a multi-functional PEG linker with two terminal propargyl groups and a t-butyl ester. The propargyl groups enables formation of triazole linkage with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry. The t-butyl protected carboxyl group can be deprotected under mild acidic conditions. | | Uses | N-(PEG2-Boc)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(PEG2-Boc)-N-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-(t-butyl ester-PEG2)-N-bis(PEG2-propargyl) Preparation Products And Raw materials |
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