AZD4320 manufacturers
- AZD4320
-
- $67.00
-
2026-07-27
- CAS:1357576-48-7
- Purity: 98.13%
- Supply Ability: 10g
- AZD4320
-
- $67.00
-
2026-07-27
- CAS:1357576-48-7
- Purity: 98.13%
- Supply Ability: 10g
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| | AZD4320 Basic information |
| Product Name: | AZD4320 | | Synonyms: | AZD4320;Benzamide, 4-[4-[(R)-(4'-chloro[1,1'-biphenyl]-2-yl)hydroxymethyl]-1-piperidinyl]-N-[[4-[[(1R)-3-[(2-hydroxyethyl)methylamino]-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-;Bcl-2 Family,Inhibitor,inhibit,AZD4320,AZD 4320,AZD-4320;4-(4-((R)-(4'-Chloro-[1,1'-biphenyl]-2-yl)(hydroxy)methyl)piperidin-1-yl)-N-((4-(((R)-4-((2-hydroxyethyl)(methyl)amino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide;AZD4320, 10 mM in DMSO | | CAS: | 1357576-48-7 | | MF: | C45H48ClF3N4O7S3 | | MW: | 945.53 | | EINECS: | | | Product Categories: | | | Mol File: | 1357576-48-7.mol |  |
| | AZD4320 Chemical Properties |
| density | 1.46±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 125 mg/mL (132.20 mM) | | form | Solid | | pka | 4.70±0.10(Predicted) | | color | White to off-white |
| | AZD4320 Usage And Synthesis |
| Uses | AZD4320 is a novel BH3-mimicking dual BCL2/BCLxL inhibitor with IC50s of 26 nM, 17 nM, and 170 nM for KPUM-MS3, KPUM-UH1, and STR-428 cells, respectively. | | IC 50 | BCL2: 17 nM (IC50, KPUM-UH1 cells); BCLxL: 17 nM (IC50, KPUM-UH1 cells) | | References | [1] Takimoto-Shimomura T, et al. Dual targeting of bromodomain-containing 4 by AZD5153 and BCL2 by AZD4320 against B-cell lymphomas concomitantly overexpressing c-MYC and BCL2. Invest New Drugs. 2018 Jun 21. DOI:10.1007/s10637-018-0623-8 |
| | AZD4320 Preparation Products And Raw materials |
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