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| | 1-Methyl-2-pyrrolidineethanol Basic information |
| | 1-Methyl-2-pyrrolidineethanol Chemical Properties |
| Boiling point | 110-112 °C14 mm Hg(lit.) | | density | 0.951 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.4713(lit.) | | Fp | 184 °F | | storage temp. | 2-8°C(protect from light) | | pka | 15.03±0.10(Predicted) | | form | clear liquid | | color | Colorless to Red to Green | | InChI | InChI=1S/C7H15NO/c1-8-5-2-3-7(8)4-6-9/h7,9H,2-6H2,1H3 | | InChIKey | FYVMBPXFPFAECB-UHFFFAOYSA-N | | SMILES | N1(C)CCCC1CCO | | CAS DataBase Reference | 67004-64-2(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22-38-41 | | Safety Statements | 26-39 | | WGK Germany | 3 | | HS Code | 29339900 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2 |
| | 1-Methyl-2-pyrrolidineethanol Usage And Synthesis |
| Chemical Properties | clear yellow to brownish liquid | | Uses | 2-(2-Hydroxyethyl)-1-methylpyrrolidine BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.
Also used in monographs such as:Clemastine Tablets | | General Description | 1-Methyl-2-pyrrolidine ethanol is an important pharmaceutical intermediate. | | Synthesis | The general procedure for the synthesis of N-methyl-2-(2-hydroxyethyl)pyrrolidine from methyl 1-methylpyrrolidine-2-acetate was as follows: 5.0 g of intermediate 2 was weighed and placed in a round-bottomed flask, and 50 mL of methanol was added to dissolve it. Subsequently, 2.0 g NaBH4 was slowly added to the reaction system, heated to reflux and kept for 12 hours. After completion of the reaction, methanol was removed by rotary evaporation under reduced pressure. To the residue, 50 mL of ethyl acetate (EA) and 50 mL of water were added, transferred to a dispensing funnel, and the organic layer was separated by sufficiently shaking and standing to separate the layers. The organic layer was washed with saturated saline and dried with anhydrous sodium sulfate. After filtration to remove the desiccant, the organic solvent was concentrated under reduced pressure to obtain 3.5 g of the target product N-methyl-2-(2-hydroxyethyl)pyrrolidine in the form of a colorless liquid. | | References | [1] Patent: KR2016/141950, 2016, A. Location in patent: Paragraph 0037 |
| | 1-Methyl-2-pyrrolidineethanol Preparation Products And Raw materials |
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